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A Diabetes Outcomes Progression Trial



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Rosiglitazone out-performs Metformin and Glyburide in terms of renal function as an early-stage type 2 diabetes treatment

19-Apr-2011
News Image ADOPT (A Diabetes Outcomes Prevention Trial) showed that initial treatment with just rosiglitazone provided more durable glycemic control than metformin or glyburide in patients with recently diagnosed type 2 diabetes. In CJASN, we examine the differences in albumin excretion, renal function and blood pressure over the course of 5 years between the treatment groups....

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More effective glycaemic control seen with rosiglitazone is explained by effects on both β-cell function and insulin sensitivity

22-Mar-2011
News Image The ADOPT study (A Diabetes Outcomes Prevention Trial) showed that treatment with rosiglitazone alone provided somewhat more effective glycaemic control than metformin or glyburide alone, in patients with recently diagnosed type 2 diabetes. In a paper published recently in Diabetes, we examined changes in β-cell function and insulin sensitivity among the three treatments in ADOPT....

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Rosiglitazone Decreases C-Reactive Protein

09-Oct-2009
News Image Rosiglitazone Decreases C-Reactive Protein to a Greater Extent Relative to Glyburide and Metformin over Four-Years in Spite of Greater Weight Gain: Observations from ADOPT (A Diabetes Outcome Progression Trial).
Steven E....

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Selected slides from the ADOPT plenary session at the IDF World Diabetes Congress 2006

05-Dec-2006


[Link]

The ADOPT results were announced at the IDF 19th World Diabetes Congress and simultaneously published in the New England Journal of Medicine.

04-Dec-2006


[Link]

Characteristics of Type 2 diabetic patients in North America and Europe

01-Dec-2006


[Link]

Presentation of results : 4th December 2006 IDF Cape Town

01-Sep-2006
See the results in a life webc...

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Demo ADOPT News item

16-Aug-2006
News will appear here.

Obesity and the association of CRP and the metabolic syndrome in T2DM

01-Aug-2006


[Link]

Patient follow up completed

01-Jul-2006

GADA prevalence in type 2 diabetes (ADOPT)

01-Dec-2004
News Image Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
Zinman B, Kahn SE, Haffner SM, O'Neill MC, Heise MA, Freed MI; ADOPT Study Group
Diabetes 2004;53:3193-3200

[Link]

Phenotypic characteristics of GAD-positive T2DM patients

01-Dec-2004


[Link]

ADOPT protocol published in Diabetes Care

01-Oct-2002
A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes.
Viberti,G; Kahn,SE; Greene,DA; Herman,WH; Zinman,B; Holman,RR; Haffner,SM; Levy,D; Lachin,JM; Berry,RA; Heise,MA; Jones,NP; Freed,MI
Diabetes Care....

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