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4-T final results published

22-Oct-2009
News Image The final 4-T results were presented during the "Latest clinical trials" symposium at the IDF World Diabetes Congress in Montreal, Canada on Thursday 22nd October 2009.

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Final results of the 4-T trial

17-Oct-2009
News Image The final three-year results of the 4-T trial will be presented at 11 am EST on Thursday 22nd October 2009 during the IDF World Diabetes Congress late breaking clinical trial session.

An overview of the results and a slide set will be available here on the 4-T web site at 11.30 am EST.

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First National ACE Investigator Meeting

11-Oct-2009
News Image ACE trial holds it's first investigator meeting in China.

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TECOS is seeking ancillary study proposals...

09-Oct-2009
News Image The Executive Committee for the Trial to Evaluate Cardiovascular Outcomes after Treatment with Sitagliptin (TECOS) will accept ancillary study proposals for review. Ancillary studies may provide valuable information beyond that explored in the context of the main trial, and will promote continued academic interest in TECOS.

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Rosiglitazone Decreases C-Reactive Protein

09-Oct-2009
News Image Rosiglitazone Decreases C-Reactive Protein to a Greater Extent Relative to Glyburide and Metformin over Four-Years in Spite of Greater Weight Gain: Observations from ADOPT (A Diabetes Outcome Progression Trial).
Steven E....

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Intensive glucose control and macrovascular outcomes in type 2 diabetes

10-Aug-2009
News Image In order to provide more precise estimates of the effects of glucose-lowering on major cardiovascular events, the Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), UKPDS and Veterans Affairs Diabetes Trial (VADT) investigators have established a collaboration to facilitate a formal meta-analysis of the results from each trial and to explore any differences among trials.

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4-T database lock

07-Aug-2009
News Image The three-year 4-T Trial last patient visit was completed in July 2009 and the database has been locked. The results will be presented at the International Diabetes Forum (IDF) in Montreal on Thursday 22nd October....

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Optimal insulin regimens in type 2 diabetes mellitus

01-Aug-2009
News Image Greater HbA1c reduction may be obtained in type 2 diabetes when insulin is initiated using biphasic or prandial insulin rather than a basal regimen, but with an unquantified risk of hypoglycaemia. Studies with longer follow-up are required to determine the clinical relevance of this finding.

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TECOS launched in Europe

29-Jul-2009
News Image TECOS (Trial Evaluating Cardiovascular Outcomes with Sitagliptin) launched in Europe in June and has recruited 30 participants to date from Hungary, Lithuania & Spain.

Centres in India, South Africa and Canada are now open and are expected to start recruiting shortly.

HTA report on self-monitoring of blood glucose

25-Jun-2009
News Image We have found no convincing evidence to recommend routine use of SMBG by reasonably well-controlled, non-insulin-treated patients with type 2 diabetes. The specific advantages of monitoring identified by patients need to be placed in the context of a decline in compliance in the more intensive monitoring group and, at best, a small reduction in HbA1c....

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Outcomes Model 1.2.1 released

03-Jun-2009
News Image Corrections
Corrected an issue on page 17 of the manual (Example #1) where the example incorrectly stated that the age entered should be 60. The correct value is 59....

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HbA1c for the diagnosis of diabetes?

01-Jun-2009
News Image An International Expert Committee with members appointed by the American Diabetes Association, the European Association for the Study of Diabetes, and the International Diabetes Federation was convened in 2008 to consider the current and future means of diagnosing diabetes in nonpregnant individuals. The report of the International Expert Committee represents the consensus view of its members and not necessarily the view of the organizations that appointed them....

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2009 Diabetes State of the Art Course presented by OCDEM and YDF

20-May-2009
12th and 13th November 2009

The Young Diabetologists Forum (YDF) and the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) have developed an educational programme for year 4 and year 5 SpRs.

This year's two-day programme will be held on the 12th ands 13th November, chaired by Professors Sir George Alberti and Rury Holman....

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Risk Engine 2.01 released

14-Apr-2009
News Image Fixes a problem in the Macintosh version where male subjects are described as female in the printout, the results printed were, however, correct. The Windows version of the software does not suffer this problem and is therefore not changed.

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New cardiovascular outcome trial with once-weekly exenatide

28-Mar-2009
A global study, sponsored by Amylin and Lilly, is being planned in conjunction with the Diabetes Trials Unit and the Duke Clinical Research Institute. The trial steering committee will be co-chaired by Professors Rury Holman and Rob Califf.

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First ACE patient enrolled 17th February 2009

19-Feb-2009
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Impact of using a non-diabetes-specific risk calculator on eligibility for statin therapy in type 2 diabetes

10-Feb-2009
News Image Price HC, Coleman RL, Stevens RJ, Holman RR
Diabetologia 2009; 52: 394-97

Aims/hypothesis
The aim of this study was to investigate the impact of using a non-diabetes-specific cardiovascular disease (CVD) risk calculator to determine eligibility for statin therapy according to current UK National Institute for Health and Clinical Excellence (NICE) guidelines for those patients with type 2 diabetes who are at an increased risk of CVD (10 year risk ≥20%).
Methods
The 10 year CVD risks were estimated using the UK Prospective Diabetes Study (UKPDS) Risk Engine and the Framingham equation for 4,025 patients enrolled in the Lipids in Diabetes Study who had established type 2 diabetes and LDL-cholesterol

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Commentary on POPADAD study

21-Jan-2009
News Image Primary prevention of cardiovascular events in diabetes: is there a role for aspirin?

Price HC, Holman RR.

The POPADAD (Prevention Of Progression of Arterial Disease And Diabetes) study did not show a benefit for low-dose aspirin therapy or administration of antioxidants for the primary prevention of cardiovascular disease events in individuals with diabetes and asymptomatic peripheral arterial disease....

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Potential impact of omega-3 treatment on cardiovascular disease in type 2 diabetes

13-Jan-2009
News Image Hartweg J, Farmer AJ, Holman RR, Neil A.

PURPOSE OF REVIEW: Hypothesis-generating systematic review of the impact of marine-derived omega-3 polyunsaturated fatty acids (PUFAs) on lipid, glycemic and hematological risk factors in type 2 diabetes using pooled data from randomized controlled trials searched up to 20 September 2008....

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AFORRD primary results published

09-Jan-2009
News Image Atorvastatin in Factorial with Omega-3 EE90 Risk Reduction in Diabetes (AFORRD): a randomised controlled trial
R. R....

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Updated version of ADA/EASD consensus algorithm for management of hyperglycaemia

09-Jan-2009
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Prevalence of Glucokinase (GCK) Mutations in Individuals Screened for Fasting Hyperglycaemia

09-Jan-2009
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