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UK Prospective Diabetes Study



Post Trial Monitoring

Intensive (sulfonylurea/insulin) versus Conventional (diet) glucose control

The UKPDS Post-Trial monitoring results showed continuing benefit of earlier improved glucose control, with maintenance of the relative risk reductions reported in 1998 for any diabetes related endpoint (9%, P=0.04) and microvascular disease (24%, P=0.001), despite loss of within trial blood glucose and antihyperglycaemic therapy differences – a legacy effect.

In addition, significant relative risk reductions emerged for myocardial infarction (15%, P=0.014) and all-cause mortality (12%, P=0.007).

Intensive (metformin) versus Conventional (diet) glucose control in overweight patients

The UKPDS Post-Trial monitoring results showed continuing benefit of earlier metformin therapy, with maintenance of the relative risk reductions reported in 1998 for any diabetes related endpoint (21%, P=0.013), myocardial infarction (33%, P=0.005) and all-cause mortality (27%, P=0.002), despite loss of within trial blood glucose and antihyperglycaemic therapy differences – a legacy effect. No significant changes were seen during or after the trial with respect to microvascular disease.

See: UKPDS 80, N Eng J Med 2008; 359 Holman et al
Download UKPDS 80 slide set here

Tight versus Less-tight blood pressure control

The UKPDS Post-Trial monitoring results showed that the risk reductions reported in 1998 for any diabetes related endpoint and for microvascular disease were not maintained following the loss of within trial blood pressure and antihypertensive therapy differences. No significant changes were seen during or after the trial with respect to myocardial infarction or all-cause mortality.

See: UKPDS 81, N Eng J Med 2008; 359 Holman et al
Download UKPDS 81 slide set here