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A Diabetes Outcomes Progression Trial ADOPT Logo

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ADOPT is a pragmatic, real-life, double-blind, randomised multicentre study which is evaluating specifically whether thiazolidinediones, with their different mode of action, can provide more durable glycaemic control than metformin or sulphonylureas. By utilising a monotherapy approach, in people with T2DM diagnosed for less than three years who are antihyperglycaemic agent naïve, ADOPT is designed to compare the relative efficacy of these three oral agents as judged primarily by the time to monotherapy failure. ADOPT will provide data on the effect of mechanistically differing treatment options on metabolic control, beta cell function, and markers of macrovascular disease risk in type 2 diabetes.

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Diabetes Trials Unit

OCDEM, Churchill Hospital, Old Road, Headington, OX3 7LJ, UK
Tel: +44 (0)1865 857240  Fax: +44 (0)1865 857241    Email: dtu@dtu.ox.ac.uk

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