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Publications (25 of 433)

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Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
Lindsay E. Clegg, Hiddo J.L. Heerspink, Robert C. Penland, Weifeng Tang, David W. Boulton, Srinivas Bachina, Robert D. Fox, Peter Fenici Marcus Thuresson, Robert J. Mentz, Adrian F. Hernandez, and Rury R. Holman
Diabetes Care 2018. Epub:06-Dec-2018. doi:10.2337/dc18-1871

Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9,259 Deaths in 9 Trials
Alexander C Fanaroff, Robert Clare, Karen S Pieper, Kenneth W Mahaffey, Chiara Melloni, Jennifer Green John H. Alexander, W. Schuyler Jones, Robert W. Harrison, Rajendra H Mehta, Thomas J. Povsic, Humberto G. Moreira, Sana M. Al-Khatib, Matthew T. Roe, David F Kong, Robin Mathews, Pierluigi Tricoci, Rury R. Holman, Lars Wallentin, Claes Held , Robert McKinnon Califf, Karen P. Alexander, and Renato D Lopes
Circulation 2018. Epub:28-Nov-2018. doi:10.1161/CIRCULATIONAHA.118.037202

Comparison of Nine Platelet Function Tests Used to Determine Responses to Different Aspirin Dosages in People with Type 2 Diabetes
Paul Harrison, M. Angelyn Bethel, Irene Kennedy, Robert Dinsdale, Ruth Coleman, Rury R. Holman
Platelets 2018. Epub:09-Jul-2018. PMID:29985735. doi:10.1080/09537104.2018.1478402


Progression of glucose-lowering diabetes therapy in TECOS
M. Angelyn Bethel, Samuel S. Engel, Susanna R. Stevens, Yuliya Lokhnygina, Jie Ding, Robert G. Josse, Michael Alvarsson, Irene Hramiak, Jennifer B. Green, Eric D. Peterson, Rury R. Holman
Endocrinol Diab Metab 2018;2:e00053. Published:13-Jan-2019. Epub:23-Dec-2018. doi:10.1002/edm2.53

Effects of blood pressure lowering on cardiovascular events, in the context of regression to the mean: a systematic review of randomized trials.
Salam A, Atkins E, Sundström J, Hirakawa Y, Ettehad D, Emdin C, Neal B, Woodward M, Chalmers J, Berge E, Yusuf S, Rahimi K, Rodgers A; Blood Pressure Lowering Treatment Trialists’ Collaboration
J Hypertens 2018;37:16-23. Published:Jan-2019. PMID:30499920. doi:10.1097/HJH.0000000000001994

Effects of Once-Weekly Exenatide on Clinical Outcomes in Patients with Preexisting Cardiovascular Disease: A Prespecified Analysis From EXSCEL
Robert J Mentz, Vivian P. Thompson, David Aguilar, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Alice P. S. Kong, Peter Öhman, Naveed Sattar, Russell S Scott, Yee Weng Wong, Rury R. Holman, and Adrian F. Hernandez
Circulation 2018;138:2576-2578. Published:27-Nov-2018. Epub:28-Aug-2018. PMID:30571356. doi:10.1161/CIRCULATIONAHA.118.036811

Metformin – 60 years of clinical experience (Chinese edition)
Ed. Ian W Campbell, Harry CS Howlett, Rury R Holman, Clifford J Bailey
ISBN 978-7-5478-4154-9 2018;1-122. Published:01-Sep-2018

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data.
Dennis JM, Henley WE, Weedon MN, Lonergan M, Rodgers LR, Jones AG, Hamilton WT, Sattar N, Janmohamed S, Holman RR, Pearson ER, Shields BM, Hattersley AT; MASTERMIND Consortium.
Diabetes Care 2018;41:1844–1853. Published:Sep-2018. Epub:02-Aug-2018. PMID:30072404. doi:10.2337/dc18-0344

What does the ACE trial tell us? – Commentary
Rury R. Holman
Journal of Diabetes 2018;10:683-685. Published:Aug-2018. Epub:17-May-2018. PMID:29774661. doi:10.1111/1753-0407.12770

Relationship between Baseline Physical Activity Assessed by Pedometer Count and New-onset Diabetes in the NAVIGATOR Trial
William E. Kraus, Thomas Yates, Jaakko Tuomilehto, Jie-Lena Sun, Laine Thomas, John J.V. McMurray, M. Angelyn Bethel, Steven M. Haffner, Rury R. Holman
BMJ Open Diabetes Research & Care 2018;6:e000523. Published:19-Jul-2018. PMID:30073088. doi:10.1136/bmjdrc-2018-000523

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes
Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA; MetGen Investigators and the ACCORD/ACCORDion Investigators.
Diabetes 2018;67:1428-1440. Published:Jul-2018. Epub:12-Apr-2018. PMID:29650774. doi:10.2337/db17-1164

Longitudinal Medical Resources and Costs Among Type 2 Diabetes Patients Participating in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)
Reed SD, Li Y, Leal J, Graham F, Radican L, Adler A, Alfredsson J, Buse JB, Green JB, Kaufman KD, Riefflin A, Van de Werf F, Peterson ED, Gray AM, Holman RR, TECOS Study Group
Diabetes Obes Metab 2018;20:1732-1739. Published:Jul-2018. Epub:23-Mar-2018. PMID:29573215. doi:10.1111/dom.13292

Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis
Lee-Ling Lim, Eric S.H. Lau, Alice P.S. Kong, Melanie J. Davies, Naomi S. Levitt, Björn Eliasson, Carlos A. Aguilar-Salinas, Guang Ning, Yutaka Seino, Wing-Yee So, Margaret McGill, Graham D. Ogle, Trevor J. Orchard, Philip Clarke, Rury R. Holman, Edward W. Gregg, Juan José Gagliardino, Juliana C.N. Chan
Diabetes Care 2018;41:1312-1320. Published:Jun-2018. PMID:29784698. doi:10.2337/dc17-2010

A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks
Matthew C. Riddle, Hertzel C. Gerstein, Rury R. Holman, Silvio Inzucchi, Bernard Zinman, Sophia Zoungas, and William T. Cefalu
Diabetes Care 2018;41:1121-1124. Published:Jun-2018. PMID:29784695. doi:10.2337/dci18-0018

Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar and Stephen Sharp
Health Technology Assessment 2018;22:1-64. Published:Apr-2018. PMID:29652246. doi:10.3310/hta22180

Class Effect for SGLT2 Inhibitors in Cardiovascular Outcomes: Implications for the Cardiovascular Disease Specialist
Bethel MA, McMurray JJV
Circulation 2018;137:1218-1220. Published:20-Mar-2018. PMID:29555706. doi:10.1161/CIRCULATIONAHA.117.030117

Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data
Kunal N. Karmali, Donald M. Lloyd-Jones, Joep van der Leeuw, David C. Goff, Jr., Salim Yusuf, Alberto Zanchetti, Paul Glasziou, Rodney Jackson, Mark Woodward, Anthony Rodgers, Bruce C. Neal, Eivind Berge, Koon Teo, Barry R. Davis, John Chalmers, Carl Pepine, Kazem Rahimi, Johan SundstroÈm, on behalf of the Blood Pressure Lowering Treatment Trialists' Collaboration
PloS Med 2018;15:e100253. Published:20-Mar-2018. PMID:29558462. doi:10.1371/journal.pmed.1002538

Increased Risk of Severe Hypoglycemic Events Before and After Cardiovascular Outcomes in TECOS Suggests an At-Risk Type 2 Diabetes Frail Patient Phenotype
Eberhard Standl, Susanna R. Stevens, Paul W. Armstrong, John B. Buse, Juliana C.N. Chan, Jennifer B. Green, John M. Lachin, Andre Scheen, Florence Travert, Frans Van de Werf, Eric D. Peterson, and Rury R. Holman, on behalf of the TECOS Study Group
Diabetes Care 2018;41:596-603. Published:Mar-2018. Epub:08-Jan-2018. PMID:29311155. doi:10.2337/dc17-1778

Management of T2DM in 2017: Clinically relevant results from cardiovascular outcome trials
Rury R Holman
Nature Reviews Endocrinology 2018;14:67-68. Published:Feb-2018. Epub:05-Jan-2018. PMID:29302077. doi:10.1038/nrendo.2017.179

Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease
S. A. Mostafa, R. L. Coleman, O. F. Agbaje, A. M. Gray, R. R. Holman and M. A. Bethel
Diabet Med. 2018;35:72-77. Published:Jan-2018. Epub:23-Oct-2017. PMID:29057545. doi:10.1111/dme.13533

Cardiovascular Outcomes Trials in Type 2 Diabetes:Where Do We Go From Here? Reflections From a Diabetes Care Editors’ Expert Forum
William T. Cefalu, Sanjay Kaul, Hertzel C. Gerstein, Rury R. Holman, Bernard Zinman, Jay S. Skyler, Jennifer B. Green, John B. Buse, Silvio E. Inzucchi, Lawrence A. Leiter, Itamar Raz, Julio Rosenstock, and Matthew C. Riddle
Diabetes Care 2018;41:14-31. Published:Jan-2018. PMID:29263194. doi:10.2337/dci17-0057

Sex differences in management and outcomes of patients with type 2 diabetes and cardiovascular disease: A report from TECOS
Alfredsson J, Green JB, Stevens SR, Reed SD, Hramiak I, White H, Armstrong PW, Bethel MA, Engel SS, McGuire DK, Van de Werf F, Peterson ED, Holman RR, on Behalf of the TECOS Study Group
Diabetes Obes Metab. 2018;20:2379-2388. Epub:19-Jun-2018. PMID:29923323. doi:10.1111/dom.13377

Effect of race on the glycaemic response to sitagliptin. Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)
Davis TME, Mulder H, Lokhnygina Y, Standl E, Aschner P, Chuang LM, Grado CR, Peterson ED, Holman RR
Diabetes, Obesity and Metabolism 2018;20:1427-1434. Epub:06-Feb-2018. PMID:29405540. doi:10.1111/dom.13242

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long- Term Glycemic Response to DPP-4 Inhibitor Therapy
John M. Dennis, Beverley M. Shields, Anita V. Hill, Bridget A. Knight, Timothy J. McDonald, Lauren R. Rodgers, Michael N. Weedon, William E. Henley, Naveed Sattar, Rury R. Holman, Ewan R. Pearson, Andrew T. Hattersley, and Angus G. Jones, on behalf of the MASTERMIND consortium
Diabetes Care 2018;41:705-712. Epub:31-Jan-2018. PMID:29386249. doi:10.2337/dc17-1827

Effect of Once-Weekly Exenatide on Clinical Outcomes According to Baseline Risk in Patients With Type 2 Diabetes Mellitus: Insights From the EXSCEL Trial
Robert J. Mentz, M. Angelyn Bethel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, João S. Felício, Shaun G. Goodman, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Renato D. Lopes, Aldo P. Maggioni, Peter Öhman, Neha J. Pagidipati, Neil R. Poulter, Ambady Ramachandran, Barry Reicher, Rury R. Holman, Adrian F. Hernandez, on behalf of the EXSCEL Study Group
J Am Heart Assoc 2018;7:e009304.. Published:--. Epub:20-Sep-2018. PMID:30371301. doi:10.1161/JAHA.118.009304