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Dr Angelyn Bethel



Publications (37 of 37)


Search Publications :

In-press or Epub

Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease
Mostafa SA, Coleman RL, Agbaje OF, Gray AM, Holman RR, Bethel MA
Diabet Med. 2017. Epub:23-Oct-2017. PMID:29057545. doi:10.1111/dme.13533

2017

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes
Rury R. Holman, M. Angelyn Bethel, Robert J. Mentz, Vivian P. Thompson, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Aldo P. Maggioni, Steven P. Marso, Peter Öhman, Neha J. Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, and Adrian F. Hernandez, for the EXSCEL Study Group
N Engl J Med 2017;377:1228-39. Published:28-Sep-2017. Epub:14-Sep-2017. PMID:28910237. doi:10.1056/NEJMoa1612917
[Slides]

Secondary Prevention of Cardiovascular Disease in Patients with Type 2 Diabetes: International 2 Insights from the TECOS Trial
Neha J. Pagidipati, Ann Marie Navar, Karen S. Pieper, Jennifer B. Green, M. Angelyn Bethel, Paul W. Armstrong, Robert G. Josse, Darren K. McGuire, Yuliya Lokhnygina, Jan H. Cornel, Sigrun Halvorsen, Timo E. Strandberg, Tuncay Delibasi, Rury R. Holman, Eric D. Peterson, On behalf of the TECOS Study Group
Circulation 2017;136:1193–1203. Published:26-Sep-2017. Epub:16-Jun-2017. PMID:28626088. doi:10.1161/CIRCULATIONAHA.117.027252

Baseline characteristics of patients enrolled in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)
Robert J. Mentz , M. Angelyn Bethel, Stephanie Gustavson, Vivian P. Thompson, Neha J. Pagidipati, John B. Buse, Juliana C. Chan, Nayyar Iqbal, Aldo P. Maggioni, Steve P. Marso, Peter Ohman, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F. Hernandez, Rury R. Holman
Am Heart J. 2017;187:1-9. Published:14-Sep-2017. Epub:12-Feb-2017. PMID:28454792. doi:10.1016/j.ahj.2017.02.005

Updated risk factors should be used to predict development of diabetes
Mary Angelyn Bethel, Kristen A. Hyland, Antonio R. Chacra, Prakash Deedwania, Gregory R. Fulcher, Rury R. Holman, Trond Jenssen, Naomi S. Levitt, John J.V. McMurray, Eleni Boutati, Laine Thomas, Jie-Lena Sun, Steven M. Haffner for the NAVIGATOR Study Group
J Diabetes Complications 2017;31:859-863. Published:May-2017. Epub:02-Mar-2017. PMID:28319004. doi:10.1016/j.jdiacomp.2017.02.012

Assessing the Safety of Sitagliptin in Older Participants in the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS)
M. Angelyn Bethel, Samuel S. Engel, Jennifer B. Green, Zhen Huang, Robert G. Josse, Keith D. Kaufman, Eberhard Standl, Shailaja Suryawanshi, Frans Van de Werf, Darren K. McGuire, Eric D. Peterson, Rury R. Holman, for the TECOS Study Group
Diabetes Care 2017;40:494–501. Published:Apr-2017. Epub:05-Jan-2017. PMID:28057693. doi:10.2337/dc16-1135

Effect of valsartan on kidney outcomes in people with impaired glucose tolerance
Currie G, Angelyn Bethel M, Holzhauer B, Haffner SM, Holman RR, McMurray JJ
Diabetes Obes Metab. 2017;19:791-799. Epub:17-Jul-2017. PMID:28093841. doi:10.1111/dom.12877

2016

Pancreatic Safety of Sitagliptin in the TECOS Study.
Buse JB, Bethel MA, Green JB, Stevens SR, Lokhnygina Y, Aschner P, Grado CR, Tankova T, Wainstein J, Josse R, Lachin JM, Engel SS, Patel K, Peterson ED, Holman RR; TECOS Study Group.
Diabetes Care 2016;40:164-170. Published:Feb-2017. Epub:14-Sep-2016. PMID:27630212. doi:10.2337/dc15-2780

Sitagliptin and Risk of Fractures in Type 2 Diabetes: Results from the TECOS Trial
Josse RG, Majumdar SR, Zheng Y, Adler A, Bethel MA, Buse JB, Green JB, Kaufman KD, Rodbard HW, Tankova T, Westerhout CM, Peterson ED, Holman RR, Armstrong PW; TECOS Study Group
Diabetes Obes Metab 2016;19:78-86.. Published:Jan-2017. Epub:08-Sep-2016. PMID:27607571. doi:10.1111/dom.12786

Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus
Darren K. McGuire,MD, MHSc; Frans Van deWerf, MD, PhD; PaulW. Armstrong, MD; Eberhard Standl, MD, PhD; Joerg Koglin, MD; Jennifer B. Green, MD; M. Angelyn Bethel, MD; Jan H. Cornel, MD; Renato D. Lopes, MD, MHS, PhD; Sigrun Halvorsen, MD; Giuseppe Ambrosio, MD; John B. Buse, MD; Robert G. Josse, MBBS; John M. Lachin, ScD; Michael J. Pencina, PhD; Jyotsna Garg, MS; Yuliya Lokhnygina, PhD; Rury R. Holman, MBChB; Eric D. Peterson, MD, MPH; for the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS) Study Group
JAMA Cardiology 2016;1:126-135. Published:May-2016. Epub:13-Apr-2016. doi:10.1001/jamacardio.2016.0103

Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial [Mandarin republication]
Rury R Holman, Mary A Bethel, Juliana CN Chan, Jean-Louis Chiasson, Zoë Doran, Junbo Ge, Hertzel Gerstein, Yong Huo, John J McMurray, Lars Ryden, Winitha Liyanage, Stefan Schröder, Michal Tendera, Michael J Theodorakis, Jaakko Tuomilehto, Wenying Yang, Dayi Hu, Changyu Pan for the ACE Study Group
Int J Endocrinol Metab 2016;36:1-4. Published:May-2016. doi:10.3760/cma.j.issn.1673-4157.201.00.00

Rationale and Design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) Trial
Rury R. Holman, M. Angelyn Bethel, Jyothis George, Harald Sourij, Zoë Doran, Joanne Keenan, Nardev S. Khurmi, Robert J. Mentz, Abderrahim Oulhaj, John B. Buse, Juliana C. Chan, Nayyar Iqbal, Sudeep Kundu, Aldo P. Maggioni, Steven P. Marso, Peter Öhman, Michael J. Pencina, Neil Poulter, Lisa E. Porter, Ambady Ramachandran, Bernard Zinman, Adrian F.Hernande
American Heart Journal 2016;174:103-110. Published:Apr-2016. Epub:21-Dec-2015. doi:10.1016/j.ahj.2015.12.009

Randomized controlled trial comparing impact on platelet reactivity of twice-daily with once-daily aspirin in people with Type 2 diabetes
M.A. Bethel, P Harrison, H Sourij, Y Sun, L Tucker, I Kennedy , S White, L Hill, A Oulhaj, R Coleman, R.R. Holman
Diabetic Medicine 2016;33:224-230. Published:Feb-2016. Epub:14-Jul-2015. PMID:26043186. doi:10.1111/dme.12828

2015

Physical activity as a determinant of fasting and 2-h post-challenge glucose: a prospective cohort analysis of the NAVIGATOR trial
T. Yates, M. J. Davies, S. M. Haffner, P. J. Schulte, L. Thomas, K. M. Huffman, C. W. Bales, D. Preiss, R. M. Califf, R. R. Holman, J. J. V. McMurray, M. A. Bethel, J. Tuomilehto and W. E. Kraus
Diabetic Medicine 2015;32:1090-1096. Published:Aug-2015. Epub:12-Apr-2015. PMID:25818859. doi:10.1111/dme.12762

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
Jennifer B. Green, M. Angelyn Bethel, Paul W. Armstrong, John B. Buse, Samuel S. Engel, Jyotsna Garg, Robert Josse, Keith D. Kaufman, Joerg Koglin, Scott Korn, John M. Lachin, Darren K. McGuire, Michael J. Pencina, Eberhard Standl, Peter P. Stein, Shailaja Suryawanshi, Frans Van de Werf, Eric D. Peterson, and Rury R. Holman, on behalf of the TECOS Study Group
N Engl J Med 2015;373:232-242. Published:16-Jul-2015. Epub:08-Jun-2015. PMID:26052984. doi:10.1056/NEJMoa1501352
Erratum in :
N Engl J Med 201;373:586, Print:06-Aug-2015, Epub:16-Jul-2015, PMID:26182233, doi:10.1056/NEJMx150029

Regional, age and sex differences in baseline characteristics of patients enrolled in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)
M. A. Bethel, J. B. Green, J.Milton, A.Tajar, S.S.Engel, R.M.Califf, R.R.Holman on behalf of the TECOS Executive Committee
Diabetes, Obesity and Metabolism 2015;17:395-402. Published:Apr-2015. Epub:13-Feb-2015. PMID:25600421. doi:10.1111/dom.12441

Pharmacological interventions for preventing or delaying onset of type 2 diabetes mellitus
M. A. Bethel, W. Xu, M. J. Theodorakis
Diabetes, Obesity and Metabolism 2015;17:231-244. Published:Mar-2015. Epub:27-Nov-2014. PMID:25312701. doi:10.1111/dom.12401

2014

Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial
Rury R Holman, Mary A Bethel, Juliana CN Chan, Jean-Louis Chiasson, Zoë Doran, Junbo Ge, Hertzel Gerstein, Yong Huo, John J McMurray, Lars Ryden, Winitha Liyanage, Stefan Schröder, Michal Tendera, Michael J Theodorakis, Jaakko Tuomilehto, Wenying Yang, Dayi Hu, Changyu Pan for the ACE Study Group
American Heart Journal 2014;168:23-29. Published:Jul-2014. Epub:05-Apr-2014. PMID:24952856. doi:10.1016/j.ahj.2014.03.021

Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: Results from NAVIGATOR
Huffman KM, Sun JL, Thomas L, Bales CW, Califf RM, Yates T, Davies MJ, Holman RR, McMurray JJ, Bethel MA, Tuomilehto J, Haffner SM, Kraus WE.
Metabolism 2014;63:554-561. Published:Apr-2014. Epub:15-Jan-2014. PMID:24559843. doi:10.1016/j.metabol.2014.01.002

Association between change in daily ambulatory activity and cardiovascular events in people with impaired glucose tolerance (NAVIGATOR trial): a cohort analysis
Thomas Yates, Steven M Haff ner, Phillip J Schulte, Laine Thomas, Kim M Huff man, Connie W Bales, Robert M Califf , Rury R Holman, John J V McMurray, M Angelyn Bethel, Jaakko Tuomilehto, Melanie J Davies, William E Kraus
Lancet 2014;383:1059-66. Published:22-Mar-2014. Epub:20-Dec-2013. PMID:24361242. doi:10.1016/S0140-6736(13)62061-9

2013

Role of diuretics, beta blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study
Lan Shen, Bimal R Shah, Eric M Reyes, Laine Thomas, Daniel Wojdyla, Peter Diem, Lawrence A Leiter, Bernard Charbonnel, Viacheslav Mareev, Edward S Horton, Steven M Haffner, Vladimir Soska, Rury Holman, M Angelyn Bethel, Frank Schaper, Jie-Lena Sun, John JV McMurray, Robert M Califf, Henry Krum
British Medical Journal 2013;347:f6745. Published:09-Dec-2013. PMID:24322398. doi:10.1136/bmj.f6745

Rationale, design, and organization of a randomized, controlled Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease
Jennifer B. Green, M. Angelyn Bethel, Sanjoy K. Paul, Arne Ring, Keith D. Kaufman, Deborah R. Shapiro, Robert M. Califf, Rury R. Holman
American Heart Journal 2013;166:983-989.e7. Published:Dec-2013. Epub:23-Oct-2013. PMID:24268212. doi:10.1016/j.ahj.2013.09.003

Incidence of atrial fibrillation in a population with impaired glucose tolerance: The contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial
Latini R, Staszewsky L, Sun JL, Bethel MA, Disertori M, Haffner SM, Holman RR, Chang F, Giles TD, Maggioni AP, Rutten GE, Standl E, Thomas L, Tognoni G, Califf RM, McMurray JJ
American Heart Journal 2013;166:935-940.e1. Published:Nov-2013. Epub:07-Oct-2013. PMID:24176451. doi:10.1016/j.ahj.2013.08.012

A Novel Risk Classification Paradigm for Patients With Impaired Glucose Tolerance and High Cardiovascular Risk
Bethel MA, Chacra AR, Deedwania P, Fulcher GR, Holman RR, Jenssen T, Kahn SE, Levitt NS, McMurray JJ, Califf RM, Raptis SA, Thomas L, Sun JL, Haffner SM
Am J Cardiol 2013;112:231-237. Published:15-Jul-2013. Epub:19-Apr-2013. PMID:23608615. doi:10.1016/j.amjcard.2013.03.019

Evaluation of a Self-Administered Oral Glucose Tolerance Test
M. Angelyn Bethel, Hermione C. Price, Harald Sourij, Sarah White, Ruth L. Coleman, Arne Ring, Irene E. C. Kennedy, Lynne Tucker, and Rury R. Holman
Diabetes Care 2013;36:1483-1488. Published:Jun-2013. Epub:15-Jan-2013. PMID:23321216. doi:10.2337/dc12-0643

2012

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials
R.J. Stevens, R.Ali, C.R. Bankhead, M.A. Bethel, B.J. Cairns, R.P. Camisasca, F.L. Crowe, A.J. Farmer, S. Harrison, J.A. Hirst, P. Home, S.E. Kahn, J.H. McLellan, R. Perera, A. Plüddemann, A. Ramachandran, N.W. Roberts, P.W. Rose, A. Schweizer, G. Viberti, R. R. Holman
Diabetologia 2012;55:2593-2603. Published:Oct-2012. Epub:10-Aug-2012. PMID:22875195. doi:10.1007/s00125-012-2653-7

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Hypertension on Clinical End Points: A Cohort Study
John J.V. McMurray, Robert M. Califf, Angelyn M. Bethel, Steven M. Haffner, Rury R. Holman
The Journal of Clinical Hypertension 2012;14:731. Published:Oct-2012. Epub:26-Jul-2012. PMID:23031154. doi:10.1111/j.1751-7176.2012.00687.x

Impact of FDA Guidance for Developing Diabetes Drugs on Trial Design: From Policy to Practice
M. Angelyn Bethel & Harald Sourij
Current Cardiology Reports 2012;14:59-69. Published:Feb-2012. Epub:18-Nov-2011. PMID:22094711. doi:10.1007/s11886-011-0229-7

2010

Baseline Characteristics of the Nateglinide and Valsartan Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial Population: Comparison with Other Diabetes Prevention Trials
Henry Krum, John J.V. McMurray, Edward Horton, Teresa Gerlock, Bjoern Holzhauer, Lineke Zuurman, Steven M. Haffner, M. Angelyn Bethel, Rury R. Holman, Robert M. Califf
Cardiovascular Therapeutics 2010;28(2):124-132. Published:29-Apr-2010. PMID:20184589. doi:10.1111/j.1755-5922.2010.00146.x

Effect of Nateglinide on the Incidence of Diabetes and Cardiovascular Events
The NAVIGATOR Study Group
N Engl J Med 2010;362:1463-76. Published:22-Apr-2010. Epub:14-Mar-2010. PMID:20228402. doi:10.1056/NEJMoa1001122
[Presentation] [Slides]

Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events
The NAVIGATOR Study Group
N Engl J Med 2010;362:1477-90. Published:22-Apr-2010. Epub:14-Mar-2010. PMID:20228403. doi:10.1056/NEJMoa1001121
[Presentation] [Slides]
Erratum in :
N Engl J Med 2010;362:1748, Print:06-May-2010

2009

Metabolic syndrome and alanine aminotransferase: a global perspective from the NAVIGATOR screening population
M. A. Bethel, P. Deedwania, N. S. Levitt, O. Schmitz, A. Huntsman-Labed, R. M. Califf, S. M. Haffner and P. Diem for the NAVIGATOR Study Groupp
Diabetic Medicine 2009;26:1204-1211. Published:Dec-2009. Epub:30-Sep-2009. PMID:20002471. doi:10.1111/j.1464-5491.2009.02864.x
[Abstract]

2008

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, David R. Matthews and H. Andrew W. Neil
N Eng J Med 2008;359:1577-89. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784090. doi:10.1056/nejmoa0806470
[Slides]

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, H. Andrew W. Neil and David R. Matthews
N Eng J Med 2008;359:1565-76. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784091. doi:10.1056/nejmoa0806359
[Slides]

Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: Rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial
Robert M. Califf, Mitradev Boolell, Steven M. Haffner, M. Angelyn Bethel, John McMurray, Anil Duggal, Rury R. Holman, for the NAVIGATOR Study Group
Am Heart J 2008;156:623-32. Published:Oct-2008. Epub:09-Sep-2008. PMID:18946890. doi:10.1016/j.ahj.2008.05.017

Determining the most appropriate components for a composite clinical trial outcome
M. Bethel, R. Holman, S. Haffner, R. Califf, A. Huntsman-Labed, T. Hua, J. McMurray
Am Heart J 2008;156:633-40. Published:Oct-2008. Epub:31-Jul-2008. PMID:18926145. doi:10.1016/j.ahj.2008.05.018

2007

Role of Lifestyle and Oral Anti Diabetic Agents to Prevent Type 2 Diabetes Mellitus and Cardiovascular Disease
M.Angelyn Bethel, Robert M. Califf
American Journal of Cardiology 2007;99:726-731. Published:01-Mar-2007. Epub:10-Jan-2007. PMID:17317381. doi:10.1016/j.amjcard.2006.09.122