DTU Logo
Overview | 4-T | ACE | ADOPT | AFORRD | DREAM | EDIT | EXSCEL | FHS | GLINT | ISAT | LDS | NAVIGATOR | TECOS | UKPDS

UK Prospective Diabetes Study

UKPDS logo


Publications (114 of 114)


Search Publications :

In-press or Epub

Health selection into neighborhoods among patients enrolled in a clinical trial
Mariana Arcaya, Ruth L. Coleman, Fahad Razak, Maria L. Alva, Rury R. Holman
Preventive Medicine Reports 2017. Epub:28-Jul-2017. doi:10.1016/j.pmedr.2017.07.003

2017

Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials
Zoungas S, Arima H, Gerstein HC, Holman RR, Woodward M, Reaven P, Hayward RA, Craven T, Coleman RL, Chalmers J; Collaborators on Trials of Lowering Glucose (CONTROL) group
Lancet Diabetes Endocrinol. 2017;5:431-437. Published:Jun-2017. Epub:29-Mar-2017. PMID:28365411. doi:10.1016/S2213-8587(17)30104-3

2015

The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
M. L. Alva, A. Gray, B. Mihaylova, J. Leal and R. R. Holman
Diabetic Medicine 2015;32:459-466. Published:Apr-2015. Epub:07-Jan-2015. PMID:25439048. doi:10.1111/dme.12647

2014

Performance of the UKPDS Outcomes Model for Prediction of Myocardial Infarction and Stroke in the ADDITION-Europe Trial Cohort: does the ADDITION validation add up?
Alastair Gray, Rury Holman, Philip Clarke, Jose Leal
Value in Health 2014;17:895-6. Published:Dec-2014. Epub:22-Sep-2014. PMID:25498785. doi:10.1016/j.jval.2014.07.008

Ethnicity and long-term vascular outcomes in Type 2 diabetes: a prospective observational study (UKPDS 83)
T. M. E. Davis, R. L. Coleman and R. R. Holman for the UKPDS Group
Diabetic Medicine 2014;31:200-207. Published:Feb-2014. Epub:22-Nov-2013. PMID:24267048. doi:10.1111/dme.12353

2013

UKPDS - The first 30 years (Mandarin version)
Holman RR, Watkins PJ
2013; . Published:18-Nov-2013

UKPDS Outcomes Model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year United Kingdom Prospective Diabetes Study: UKPDS 82
Hayes AJ, Leal J, Gray AM, Holman RR, Clarke PM
Diabetologia 2013;56:1925-1933. Published:Sep-2013. Epub:22-Jun-2013. PMID:23793713. doi:10.1007/s00125-013-2940-y

Temporal Validation of the UKPDS Outcomes Model Using 10-Year Post trial Monitoring Data
Leal J, Hayes AJ, Gray AM, Holman RR, Clarke PM.
Diabetes Care 2013;36:1541-1546. Published:Jun-2013. Epub:28-Dec-2012. PMID:23275370. doi:10.2337/dc12-1120

Prognostic Significance of Silent Myocardial Infarction in Newly-Diagnosed Type 2 Diabetes: UKPDS 79
Timothy M.E. Davis; Ruth L. Coleman; Rury R. Holman
Circulation 2013;127:980-987. Published:05-Mar-2013. Epub:29-Jan-2013. PMID:23362315. doi:10.1161/CIRCULATIONAHA.112.000908

2009

Addition of Insulin to Oral Therapy in Type 2 Diabetes
Holman RR, Matthews DM, Neil HAW
N Eng J Med 2009;360:418. Published:24-Jun-2009

2008

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, David R. Matthews and H. Andrew W. Neil
N Eng J Med 2008;359:1577-89. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784090. doi:10.1056/nejmoa0806470
[Slides]

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes
Rury R. Holman, Sanjoy K. Paul, M. Angelyn Bethel, H. Andrew W. Neil and David R. Matthews
N Eng J Med 2008;359:1565-76. Published:09-Oct-2008. Epub:10-Sep-2008. PMID:18784091. doi:10.1056/nejmoa0806359
[Slides]

2007

Impact of the metabolic syndrome on macrovascular and microvascular outcomes in type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study 78
Carole A. Cull, Christine C. Jensen, Ravi Retnakaran and Rury R. Holman
Circulation 2007;116:2119-2126. Published:06-Nov-2007. Epub:22-Oct-2007. PMID:17967769. doi:10.1161/CIRCULATIONAHA.107.733428
[Abstract]

An association analysis of the HLA gene region in latent autoimmune diabetes in adults
M. Desai, E. Zeggini, V. A. Horton, K. R. Owen, A. T. Hattersley, J. C. Levy, M. Walker, K. M. Gillespie, P. J. Bingley, G. A. Hitman, R. R. Holman, M. I. McCarthy and A. Clark
Diabetologia 2007;50:68-73. Published:Jan-2007. Epub:02-Dec-2006. PMID:17143607. doi:10.1007/s00125-006-0513-z
[Abstract]

Metformin as First Choice in oral Diabetes Treatment: the UKPDS experience
Holman R
Journ Annu Diabetol Hotel Dieu 2007;13:13-20. Published:Jan-2007. PMID:18613325
[Full text]

2006

Paraoxonase2 (PON2) Polymorphisms and Development of Renal Dysfunction in Type 2 Diabetes: UKPDS 76
Calle R, McCarthy MI, Banerjee P, Zeggini E, Cull CA, Thorne KI, Wiltshire S, Terra S, Meyer D, Richmond J, Mancuso J, Milos P, Fryburg D, Holman RR
Diabetologia 2006;49:2892-2899. Published:Dec-2006. Epub:03-Oct-2006. PMID:17096118. doi:10.1007/s00125-006-0436-8
[Abstract]

Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73
Wright AD, Cull CA, Macleod KM, Holman RR for the UKPDS Group
J Diabetes Complications 2006;20:402-408. Published:Nov-2006. Epub:25-Oct-2006. PMID:17070446. doi:10.1016/j.jdiacomp.2005.08.010
[Abstract]

A Clinical Screening Tool Identifies Autoimmune Diabetes in Adults: Response to Fourlanos et al.
Timothy M.E. Davis, Carole A. Cull and Rury R. Holman
Diabetes Care 2006;29:2560. Published:Nov-2006. PMID:17065707. doi:10.2337/dc06-1321

Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75)
Stratton IM, Cull CA, Adler AI, Matthews DR, Neil HA, Holman RR
Diabetologia 2006;49:1761-1769. Published:Aug-2006. Epub:31-May-2006. PMID:16736131. doi:10.1007/s00125-006-0297-1
[Abstract]

Risk Factors for Renal Dysfunction in Type 2 Diabetes
Retnakaran R, Cull CA, Thorne KI, Adler AI, Holman RR for the UKPDS study group
Diabetes 2006;55:1832-1839. Published:Jun-2006. PMID:16731850. doi:10.2337/db05-1620
[Abstract]

The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults
Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M, Holman RR, McCarthy MI, Clark A
Diabetes 2006;55:1890-1894. Published:Jun-2006. PMID:16731859. doi:10.2337/db06-0089
[Abstract]

Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective
Holman RR
Metabolism Clinical and Experimental 2006;55 (Suppl 1):S2-S5. Published:May-2006. PMID:16631806. doi:10.1016/j.metabol.2006.02.006
[Abstract]

2005

Reporting of diabetes on death certificates using data from the UK Prospective Diabetes Study
Thomason MJ, Biddulph JP, Cull CA, Holman RR
Diabetic Medicine 2005;22:1031-1036. Published:Aug-2005. Epub:02-Mar-2005. PMID:16026369. doi:10.1111/j.1464-5491.2005.01584.x

Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72)
Clarke PM, Gray AM, Briggs A, Stevens RJ, Matthews DR, Holman RR
Diabetologia 2005;48:868-877. Published:May-2005. Epub:15-Apr-2005. PMID:15834550. doi:10.1007/s00125-005-1717-3

IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes
G. F. Bottazzo, E. Bosi, C. A. Cull, E. Bonifacio, M. Locatelli, P. Zimmet, I. R. Mackay, R. R. Holman
Diabetologia 2005;48:703-708. Published:Apr-2005. Epub:12-Mar-2005. PMID:15765222. doi:10.1007/s00125-005-1691-9
Erratum in :
Diabetologia 2005;48:1240, Epub:19-May-2005, doi:10.1007/s00125-005-1808-1

Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control
T. M. E. Davis, A. D. Wright, Z. M. Mehta, C. A. Cull, I. M. Stratton, G. F. Bottazzo, E. Bosi, I. R. Mackay, R. R. Holman
Diabetologia 2005;48:695-702. Published:Apr-2005. Epub:24-Feb-2005. PMID:15729570. doi:10.1007/s00125-005-1690-x

2004

Insulin sensitivity at diagnosis of Type 2 diabetes is not associated with subsequent cardiovascular disease (UKPDS 67)
Adler AI, Levy JC, Matthews DR, Stratton IM, Hines G, Holman RR
Diabetic Medicine 2004;22:306-311. Published:Mar-2005. Epub:02-Dec-2004. PMID:15717879. doi:10.1111/j.1464-5491.2004.01418.x
[Abstract]

Changing aspirin use in patients with Type 2 diabetes in the UKPDS
Cull CA, Neil HAW, Holman RR
Diabetic Medicine 2004;21:1368-1371. Published:Dec-2004. Epub:24-Nov-2004. PMID:15569143. doi:10.1111/j.1464-5491.2004.01328.x
[Abstract]

Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus
Matthews DR, Stratton IM, Aldington SJ, Holman RR, Kohner EM for the UK Prospective Diabetes Study Group
Archives of Ophthalmology 2004;122:1631-1640. Published:Nov-2004. PMID:15534123. doi:10.1001/archopht.122.11.1631

A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS 68)
P. M. Clarke, A. M. Gray, A. Briggs, A. J. Farmer, P. Fenn, R. J. Stevens, D. R. Matthews, I. M. Stratton, R. R. Holman
Diabetologia 2004;47:1747-1759. Published:Oct-2004. Epub:27-Oct-2004. PMID:15517152. doi:10.1007/s00125-004-1527-z

Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66
Stevens RJ, Coleman RL, Adler AI, Stratton IM, Matthews DR, Holman RR
Diabetes Care 2004;27:201-207. Published:Jan-2004. PMID:14693990. doi:10.2337/diacare.27.1.201
[Abstract]

2003

Poor pregnancy outcome for women with Type 2 diabetes
Hadden DR, Cull CA, Croft DJ, Holman RR
Diabetic Medicine 2003;20:506-507. Published:Jun-2003. Epub:18-Jul-2003. PMID:12786690. doi:10.1046/j.1464-5491.2003.00955_2.x

The impact of diabetes-related complications on healthcare costs: results from the United Kingdom Prospective Diabetes Study (UKPDS Study No 65)
Clarke P, Gray A, Legood R, Briggs A, Holman R
Diabetic Medicine 2003;20:442-450. Published:Jun-2003. Epub:18-Jul-2003. PMID:12786677. doi:10.1046/j.1464-5491.2003.00972.x

Autoantibodies to the islet cell antigen SOX-13 areassociated with duration but not type of diabetes
Davis TM, Mehta Z, Mackay IR, Cull CA, Bruce DG, Fida S, Rowley MJ, Holman RR
Diabetic Medicine 2003;20:198-204. Published:Mar-2003. Epub:10-Mar-2003. PMID:12675663. doi:10.1046/j.1464-5491.2003.00897.x
[Abstract]

Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64)
Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR for the UKPDS Group
Kidney International 2003;63:225-232. Published:Jan-2003. PMID:12472787. doi:10.1046/j.1523-1755.2003.00712.x
[Abstract]

2002

Modeling glucose exposure as a risk factor for photocoagulation in type 2 diabetes.
Stevens RJ, Stratton IM, Holman RR.
J Diabetes Complications 2002;16:371-376. Published:Nov-2002. Epub:04-Dec-2002. PMID:12477619. doi:10.1016/S1056-8727(02)00161-7
[Abstract]

The economics of translating trial evidence into practice: costs of implementing more intensive glycaemic and blood pressure control in type 2 diabetes in England
Gray A, Clarke P, Farmer A, Holman R for the United Kingdom Prospective Diabetes Study (UKPDS) Group
British Medical Journal 2002;325:1-6. Published:19-Oct-2002. PMID:12386035. doi:10.1136/bmj.325.7369.860
[Abstract]

Are Lower Fasting Plasma Glucose Levels at Diagnosis of Type 2 Diabetes Associated with Improved Outcomes?
Colagiuri S, Cull CA, Holman RR
Diabetes Care 2002;25:1410-1417. Published:Aug-2002. PMID:12145243. doi:10.2337/diacare.25.5.894
[Abstract]

Estimating utility values for health states of type 2 diabetic patients using the EQ-5D
Clarke P, Gray A, Holman R
Medical Decision Making 2002;4:340-349. Published:Aug-2002. PMID:12150599. doi:10.1177/0272989X0202200412

Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine
Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HA, Holman RR
Stroke 2002;33:1776-1781. Published:Jul-2002. PMID:12105351. doi:10.1161/01.STR.0000020091.07144.C7
[Abstract]

Hyperglycemia and Other Potentially Modifiable Risk Factors for Peripheral Vascular Disease in Type 2 Diabetes.
Adler AI, Stevens RJ, Neil A, Stratton IM, Boulton AJ, Holman RR
Diabetes Care 2002;25:894-899. Published:May-2002. PMID:11978687. doi:10.2337/diacare.25.5.894
[Abstract]

Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57)
Wright A, Burden ACF, Paisey RB, Cull CA, Holman RR.
Diabetes Care 2002;25:330-336. Published:Feb-2002. PMID:11815505. doi:10.2337/diacare.25.2.330
[Abstract]
Erratum in :
Diabetes Care 2002;25:1268, Print:Jul-2002, doi:10.2337/diacare.25.7.1268

Standardization of glycated haemoglobin
Marshall SM, Home PD, Manley SM, Barth JH, John WG.
Annals of Clinical Biochemistry 2002;39:77-79. Published:Jan-2002. PMID:11853199

Analysis of the United Kingdom Prospective Diabetes Study
Holman RR
Endocrine Practice 2002;8 Supplement 1:33-34. Published:Jan-2002. doi:10.4158/EP.8.S1.33
[Abstract]

Calculation of coronary risk in Type 2 diabetes: another cause for concern: authors' reply
Holman RR, Manley SE, Stevens RJ on behalf of the UKPDS Study Group
Clinical Science 2002;103:217-219. Published:01-Aug-2001. doi:10.1042/cs1030217v

2001

The UKPDS: implications for the dyslipidaemic patient
Holman R
Acta Diabetologica 2001;38 Suppl 1:S9-S14. Published:Sep-2006. PMID:11829452. doi:10.1007/s005920170003
[Abstract]

The UKPDS Risk Engine: a model for the risk of coronary heart disease in type 2 diabetes
Stevens RJ, Kothari V, Adler AI, Stratton IM; United Kingdom Prospective Diabetes Study (UKPDS) Group
Clinical Science 2001;101:671-679. Published:Dec-2001. PMID:11724655. doi:10.1042/cs1010671
[Abstract]
Erratum in :
Clinical Science 2002;102:679, Print:Jun-2002, doi:10.1042/cs1020679

Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies.
Clarke R, Lewington S, Donald A, Johnston C, Refsum H, Stratton IM, Jacques P, Breteler MMB, Holman R
Journal of Cardiovascular Risk 2001;8:363-369. Published:Dec-2001. PMID:11873092
[Full text] [Abstract]

Butyrylcholinesterase K variant on chromsome 3q is associated with Type II diabetes in white Caucasian subjects
Hashim Y, Shepherd D, Wiltshire S, Holman RR, Levy JC, Clark A, et al.
Diabetologia 2001;44:2227-2230. Published:Dec-2001. PMID:11793025. doi:10.1007/s001250100033
[Abstract]
Erratum in :
Diabetologia 2002;45:459, Print:Mar-2002

Relationship between ethnicity and glycaemic control, lipid profiles and blood pressure during the first nine years of Type 2 diabetes
Davis TM, Cull CA, Holman RR; U.K. Prospective Diabetes Study (UKPDS) Group
Diabetes Care 2001;24:1167-1173. Published:Jul-2001. PMID:11423497. doi:10.2337/diacare.24.7.1167
[Abstract]

An economic evaluation of atenolol versus captopril in patients with Type 2 diabetes
Gray A, Clarke P, Raikou M, Stevens R, Neil A, Cull C, Stratton I, Holman R
Diabetes Medicine 2001;18:438-444. Published:Jun-2001. Epub:20-Dec-2001. PMID:11472461. doi:10.1046/j.1464-5491.2001.00485.x
[Abstract]

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)
Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC.
Diabetic Medicine 2001;18:206-12. Published:Mar-2001. Epub:20-Dec-2001. PMID:11318841. doi:10.1046/j.1464-5491.2001.00449.x
[Abstract]
Erratum in :
Diabetic Medicine 2003;20:252, Print:Mar-2003

Relationship between the severity of retinopathy and progression to photocoagulation in patients with Type 2 diabetes mellitus in the UKPDS (UKPDS 52)
Kohner EM, Stratton IM, Aldington SJ, Holman RR, Matthews DR.
Diabetic Medicine 2001;18:178-184. Published:Mar-2001. Epub:20-Dec-2001. PMID:11318837. doi:10.1046/j.1464-5491.2001.00458.x
[Abstract]

Cost-effective analysis of intensive blood glucose control with metformin in overweight patients with type 2 diabetes (UKPDS 51).
Clarke P, Gray A, Adler A, Stevens R, Raikou M, Cull C, Stratton I, Holman R; UKPDS Group. United Kingdom Prospective Diabetes Study
Diabetologia 2001;44:298-304. Published:Mar-2001. PMID:11317659. doi:10.1007/s001250051617
[Abstract]

UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis
Stratton IM, Kohner EM, Aldington SJ, Turner RC, Manley SE, Matthews DR
Diabetologia 2001;44:1546-163. Published:Feb-2001. PMID:11270671. doi:10.1007/s001250051594
[Abstract]

2000

Life-expectancy projection by modelling and computer simulation (UKPDS 46)
Stevens R, Adler A, Gray A, Briggs A, Holman R.
Diabetes Research and Clinical Practice 2000;50:S5-S13. Published:Nov-2000. Epub:13-Nov-2000. PMID:11080560. doi:10.1016/S0168-8227(00)00214-X
[Abstract]

Seeing what you want to see in randomised controlled trials. Authors' choice of study was ill informed
Holman RR
British Medical Journal 2000;321:1078-1079. Published:28-Oct-2000. PMID:11053192. doi:10.1136/bmj.321.7268.1078
[Abstract]

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR
British Medical Journal 2000;321:412-419. Published:12-Aug-2000. PMID:10938049. doi:10.1136/bmj.321.7258.412
[Abstract] [Slides]
Erratum in :
British Medical Journal 2001;322:90, Print:13-Jan-2001

Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes: prospective observational study.
Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR
British Medical Journal 2000;321:405-412. Published:12-Aug-2000. PMID:10938048. doi:10.1136/bmj.321.7258.405
[Abstract] [Slides]

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR
British Medical Journal 2000;321:412-419. Published:12-Aug-2000. PMID:10938049. doi:10.1136/bmj.321.7258.412
[Abstract] [Slides]
Erratum in :
British Medical Journal 2001;322:90, Print:13-Jan-2001

Effects of three months' diet after diagnosis of type 2 diabetes on plasma lipids and lipoproteins
Manley SM, Stratton IM, Cull CA, Fighi V, Eeley EA, Matthews DR, Holman RR, Turner RC
Diabetic Medicine 2000;17:518-523. Published:Jul-2000. PMID:10972581. doi:10.1046/j.1464-5491.2000.00320.x
[Abstract]

Cost-effective analysis of intensive blood glucose control with metformin in overweight patients with type 2 diabetes.
Gray A, Raikou M, McGuire A, Fenn P, Stevens R, Cull C, Stratton I, Adler A, Holman R, Turner R
British Medical Journal 2000;320:1373-1378. Published:20-May-2000. PMID:10818026. doi:10.1136/bmj.320.7246.1373
[Abstract]

1999

Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47)
Adler AI, Neil AW, Manley SE, Holman RR, Turner RC
Am Heart J 1999;138:S353-S359. Published:11-Sep-2006. PMID:10539797. doi:10.1016/S0002-8703(99)70035-9
[Abstract]

Sequence variants of the sarco(endo)plasmic reticulum Ca2+-transport ATPase 3 gene (SERCA3) are associated with Type 2 diabetes in Caucasians
Varadi A, Lebel L, Hashim Y, Mehta Z, Ashcroft SJH, Turner RC
Diabetologia 1999;42:1240-1243. Published:Sep-1999. PMID:10525666. doi:10.1007/s001250051298
[Abstract]

Microaneurysms in the development of diabetic retinopathy
Kohner EM, Stratton IM, Adlington SJ, Turner RC
Diabetologia 1999;42:1107-1112. Published:Sep-1999. PMID:10447523. doi:10.1007/s001250051278
[Abstract]

UKPDS: What was the question? UK Prospective Diabetes Study
Turner R, Holman R, Butterfield J
Lancet 1999;354:600. Published:14-Aug-1999. PMID:10470732. doi:10.1016/S0140-6736(05)77957-5

Randomised, double-blind trial of acarbose in type 2 diabetes shows improved glycaemic control over three years
Holman RR, Cull CA, Turner RC
Diabetes Care 1999;22:960-964. Published:Jul-1999. PMID:10372249. doi:10.2337/diacare.22.6.960
[Abstract]
Erratum in :
Diabetes Care 1999;22:1922, Print:Nov-1999

Quality of life in type 2 diabetic patients is affected by complications but not by intensive policies to improve blood glucose or blood pressure control
UKPDS Group
Diabetes Care 1999;22:1125-1136. Published:Jul-1999. PMID:10388978. doi:10.2337/diacare.22.7.1125
[Abstract]

Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus: Progressive Requirement for Multiple Therapies (UKPDS 49)
Turner RC, Cull CA, Frighi V, Holman RR
JAMA 1999;281:2005-2012. Published:02-Jun-1999. PMID:10359389. doi:10.1001/jama.281.21.2005
[Abstract]

Risk factors for stroke in non-insulin dependent diabetes mellitus
Davies TME, Millns H, Stratton IM, Holman RR, Turner RC
Arch Intern Med 1999;159:1097-1103. Published:24-May-1999. PMID:10335687. doi:10.1001/archinte.159.10.1097
[Abstract]

Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group
Horton VA, Stratton IM, Bottazzo GF, Shattock M, MacKay I, Zimmett P, Manley SE, Holman RR, Turner RC
Diabetologia 1999;42:608-616. Published:May-1999. PMID:10333055. doi:10.1007/s001250051202
[Abstract]

Hepatocyte nuclear factor-1alpha (the MODY3 gene) mutations in late onset Type 2 diabetes in the UK.
Cox RD, Sotham L, Hashim Y, Horton V, Mehta Z, Taghavi J, Lathrop M, Turner RC
Diabetes 1999;42:120-121. Published:Jan-1999. PMID:10027593. doi:10.1007/s001250051127

1998

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
UKPDS Group
British Medical Journal 1998;317:703-713. Published:12-Sep-1998. PMID:9732337. doi:10.1136/bmj.317.7160.703
[Abstract]

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes
UKPDS Group
British Medical Journal 1998;317:713-720. Published:12-Sep-1998. PMID:9732338. doi:10.1136/bmj.317.7160.713
[Abstract]

Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes
UKPDS Group
British Medical Journal 1998;317:720-726. Published:12-Sep-1998. PMID:9732339. doi:10.1136/bmj.317.7160.720
[Abstract]

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
UKPDS Group
Lancet 1998;352:837-853. Published:12-Sep-1998. PMID:9742976. doi:10.1016/S0140-6736(98)07019-6
[Abstract]
Erratum in :
Lancet 1999;354:602, Print:14-Aug-1999

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
UKPDS Group
Lancet 1998;352:854-865. Published:12-Sep-1998. PMID:9742977. doi:10.1016/S0140-6736(98)07037-8
[Abstract]
Erratum in :
Lancet 1998;352:1558, Print:07-Nov-1998, doi:10.1016/S0140-6736(05)60381-9

Ethnicity and cardiovascular disease. The incidence of myocardial infarction in white, South Asian, and Afro-Caribbean patients with type 2 diabetes (U.K. Prospective Diabetes Study 32)
UKPDS Group
Diabetes Care 1998;21:1271-1277. Published:Aug-1998. PMID:9702432. doi:10.2337/diacare.21.8.1271
[Abstract]

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC
Diabetic Medicine 1998;15:297-303. Published:Apr-1998. PMID:9585394. doi:10.1002/(SICI)1096-9136(199804)15:4<297::AID-DIA572>3.0.CO;2-W
[Abstract]

Risk factors for coronary artery disease in non-insulin dependent diabetes
UKPDS Group
British Medical Journal 1998 1998;316:823-828. Published:14-Mar-1998. PMID:9549452. doi:10.1136/bmj.316.7134.823
[Abstract]

United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors
UKPDS Group
Archives of Ophthalmology 1998;116:297-303. Published:Mar-1998. PMID:9514482. doi:10.1001/archopht.116.3.297
[Abstract]

United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy
UKPDS Group
Annals of internal medicine 1998;128:165-175. Published:01-Feb-1998. PMID:9454524. doi:10.7326/0003-4819-128-3-199802010-00001
[Abstract]

UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes
UKPDS Group
Diabetes Care 1998;21:87-92. Published:Jan-1998. PMID:9538975. doi:10.2337/diacare.21.1.87
[Abstract]

1997

Progressive Hyperglycaemia: the UKPDS Experience
Holman RR
Consultant (Supp) 1997;37:530-536. Published:11-Sep-2006
[Abstract]

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
UKPDS Group
Lancet 1997;350:1288-1293. Published:01-Nov-1997. PMID:9357409. doi:10.1016/S0140-6736(97)03062-6
[Abstract]
Erratum in :
Lancet 1998;351:376, Print:31-Jan-1998, doi:10.1016/S0140-6736(05)78287-8

U.K. Prospective Diabetes Study 27. Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex
UKPDS Group
Diabetes Care 1997;20:1683-1687. Published:Nov-1997. PMID:9353608. doi:10.2337/diacare.20.11.1683
[Abstract]

U.K. Prospective Diabetes Study 22. Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM
UKPDS Group
Diabetes Care 1997;20:1435-1441. Published:Sep-1997. PMID:9283793. doi:10.2337/diacare.20.9.1435
[Abstract]

Coronary heart disease and risk factors in NIDDM - experience from the United Kingdom Prospective Diabetes Study
R. C. Turner, H. Millns, R. R. Holman
Diabetologia 1997;40 Supplement 2:S121-S122. Published:Jun-1997. PMID:9248716. doi:10.1007/s001250051424

UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects
UKPDS Group
J Clin Endocrinol Metab 1997;82:654-657. Published:Feb-1997. PMID:9024271. doi:10.1210/jcem.82.2.3744
[Abstract]

UKPDS 21: low prevalence of the mitochondrial transfer RNA gene (tRNA(Leu(UUR))) mutation at position 3243bp in UK Caucasian type 2 diabetic patients
Saker PJ, Hattersley AT, Barrow B, Hammersley MS, Vorton H, Gillmer MD, Turner RC
Diabetic Medicine 1997;14:42-45. Published:Jan-1997. PMID:9017352. doi:10.1002/(SICI)1096-9136(199701)14:1<42::AID-DIA295>3.0.CO;2-T
[Abstract]

1996

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations
Zhang Y, Wat N, Stratton IM, Warren-Perry MG, Orho M, Groop L, Turner RC
Diabetolgia 1996;39:1505-1511. Published:Dec-1996. PMID:8960833. doi:10.1007/s001250050605
[Abstract]

The UK Prospective Diabetes Study
Turner RC, Holman RR
Annals of Medicine 1996;28:439-444. Published:Oct-1996. PMID:8949976
[Abstract]

UKPDS 18: estimated dietary intake in type 2 diabetic patients randomly allocated to diet, sulphonylurea or insulin therapy
UKPDS Group
Diabetic Medicine 1996;13:656-662. Published:Jul-1996. PMID:8840101. doi:10.1002/(SICI)1096-9136(199607)13:7<656::AID-DIA131>3.0.CO;2-5
[Abstract]

U.K. Prospective Diabetes Study
Turner RC, Cull CA, Holman RR
Diabetes Care 1996;19:182-183. Published:Feb-1996. PMID:8718447. doi:10.2337/diacare.19.2.182

United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus
UKPDS Group
Annals of Internal Medicine 1996;124:136-145. Published:01-Jan-1996. PMID:8554206. doi:10.7326/0003-4819-124-1_Part_2-199601011-00011
[Abstract]

1995

U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM
Dudley CRK, Keavney B, Stratton IM, Turner RC
Kidney International 1995;48:1907-1911. Published:Dec-1995. PMID:8587251. doi:10.1038/ki.1995.490
[Abstract]

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
UKPDS Group
Diabetes 1995;44:1249-1258. Published:Nov-1995. PMID:7589820. doi:10.2337/diab.44.11.1249
[Abstract]

UK prospective diabetes study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM
Keavney BD, Dudley CRK, Stratton IM, Holman RR, Matthews DR, Ratcliffe PJ, Turner RC
Diabetologia 1995;38:948-952. Published:Aug-1995. PMID:7589881. doi:10.1007/BF00400584
[Abstract]

Lessons from UK Prospective Diabetes Study
Turner RC, Holman RR
Diabetes Research and Clinical Practice 1995;28:S151-S157. Published:Aug-1995. PMID:8529508. doi:10.1016/0168-8227(95)01105-M
[Abstract]

Relative Efficacy of Randomly allocated Diet, Sulphonylurea, Insulin, or Metformin in Patients with newly diagnosed non-insulin dependent diabetes followed for three years
Holman RR, Cull CA, Fox C, Turner RC
British Medical Journal 1995;310:83-88. Published:14-Jan-1995. PMID:7833731. doi:10.1136/bmj.310.6972.83
[Abstract]

UK Prospective Diabetes Study: 3-year update
Holman RR for the UKPDS Group
New Horizons in Diabetes Mellitus and Cardiovascular Disease, Current Science Press. Ed Born GVR, Schwartz J. 1995;183-186. Published:Jan-1995

1994

UK Prospective Diabetes Study. XII: Differences between Asian, Afro-Caribbean and white Caucasian type 2 diabetic patients at diagnosis of diabetes
Meyer LC, Manley SE, Frighi V, Burden F, Neil HAW, Holman RR, Turner RC
Diabetic Medicine 1994;11:670-677. Published:Aug-1994. PMID:7955993. doi:10.1111/j.1464-5491.1994.tb00331.x
[Abstract]

UK Prospective Diabetes Study (UKPDS). XI: Biochemical risk factors in type 2 diabetic patients at diagnosis compared with age-matched normal subjects
Manley SE, Meyer LC, Neil HAW, Ross IS, Turner RC, Holman RR
Diabetic Medicine 1994;11:534-544. Published:Jul-1994. PMID:7955969. doi:10.1111/j.1464-5491.1994.tb02032.x
[Abstract]

1993

L'Etude UKPDS Sur Le Controle De La Glycemie Et De L'Hypertension Arterielle Dans Le Diabete De type 2: Objectifs, Structure Et Resultats Preminiaires [The UKPDS study on glycemic control and arterial hypertension in type II diabetes: objectives, structure and preliminary results]
Levy JC, Cull CA, Stratton IM, Holman RR, Turner RC
Journ Annu Diabetol Hotel Dieu 1993;123-37. Published:11-Sep-2006. PMID:8331860

UK Prospective Diabetes Study (UKPDS). X. Urinary albumin excretion over 3 years in diet-treated type 2, (non-insulin-dependent) diabetic patients, and association with hypertension, hyperglycaemia and hypertriglyceridaemia
Cull CA, Manley S, Frighi V, Holman RR, Turner RC
Diabetologia 1993;36:1021-1029. Published:Oct-1993. PMID:8243850. doi:10.1007/BF02374494
[Abstract]

UK Prospective Diabetes Study (UKPDS). IX: Relationships of urinary albumin and N-acetylglucosaminidase to glycaemia and hypertension at diagnosis of type 2 (non-insulin-dependent) diabetes mellitus and after 3 months diet therapy
UKPDS Study Group
Diabetologia 1993;36:835-842. Published:Sep-1993. PMID:8405755. doi:10.1007/BF00400359
[Abstract]

1991

UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance
Turner RC, Holman RR, Matthews DR, Oakes SF, Bassett PA, Stratton IM, Cull CA, Manley SE, Frighi V
Diabetologia 1991;34:877-890. Published:Dec-1991. PMID:1778353. doi:10.1007/BF00400195
[Abstract]

1990

Response of fasting plasma glucose to diet therapy in newly-presenting Type 2 diabetic patients
UKPDS Study Group
Metabolism 1990;39:905-912. Published:Sep-1990. PMID:2392060. doi:10.1016/0026-0495(90)90299-R
[Abstract]

UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors
UKPDS Study Group
Diabetes Research 1990;13:1-11. Published:Jan-1990. PMID:2097090
[Abstract]

1988

Characteristics of newly presenting type 2 diabetic patients: estimated insulin sensitivity and islet beta-cell function
UKPDS Study Group
Diabetic Medicine 1988;5:444-448. Published:Jul-1988. PMID:2970917. doi:10.1111/j.1464-5491.1988.tb01025.x
[Abstract]

Characteristics of newly-presenting type 2 diabetic patients: male preponderance and obesity at different ages
UKPDS Study Group
Diabetic Medicine 1988;5:154-159. Published:Mar-1988. PMID:2964982. doi:10.1111/j.1464-5491.1988.tb00963.x
[Abstract]

1985

United Kingdom Prospective Diabetes Study. III. Prevalence of hypertension and hypotensive therapy in patients with newly diagnosed diabetes. A multicenter study
UKPDS Study Group
Hypertension 1985;7:11-13. Published:Nov-1985. PMID:4077242. doi:10.1161/01.HYP.7.6_Pt_2.II8
[Abstract]

U.K. prospective diabetes study. II. Reduction in HbA1c with basal insulin supplement, sulfonylurea, or biguanide therapy in maturity-onset diabetes. A multicenter study
UKPDS Study Group
Diabetes 1985;34:793-798. Published:Aug-1985. PMID:2862087. doi:10.2337/diab.34.8.793
[Abstract]

1983

UK prospective study of therapies of maturity-onset diabetes. I. Effect of diet, sulphonylurea, insulin or biguanide therapy on fasting plasma glucose and body weight over one year
UKPDS Study Group
Diabetologia 1983;24:404-411. Published:Jun-1983. PMID:6350078. doi:10.1007/BF00257337
[Abstract]