Diabetes Trials Unit

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The Diabetes Trials Unit (DTU), founded in 1985 by Professor Rury Holman, specialises in performing diabetes-related national and multinational mega trials in partnership with the NHS, NIH, MRC, BHF, DUK, academic institutions and industry. The DTU also undertakes major modelling and statistical programmes to utilise fully the data available from its many studies, with a particular emphasis on modelling diabetes and cardiovascular disease processes. Current studies include 4-T, ACE, TECOS and EXSCEL. [More...]

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2013	May	TRG Research Bulletin 10 - 2013
	March	The Global Reach of TECOS
		OxBRC OCDEM Clinical & Non-Clinical Research Fellowships
		Senior Clinical Researcher vacancy
	February	New study suggests one in six people with newly-diagnosed diabetes may have had a silent heart attack in the past
	January	TRG Research Bulletin - Spring 2013
		New DTU study finds that screening for diabetes could be done at home
2012	December	DTU now part of Oxford's newly-created Radcliffe Department of Medicine
	November	DTU Director gives invited talks in Chile and the US
		New DTU video encourages people to participate in diabetes trials
		TRG Research Bulletin - Autumn 2012
	October	Applications sought for two prestigious NIHR Oxford BRC Clinical Fellowships in Diabetes
		Oxford University ranked top in the world for medicine
	September	First CIDE Visiting Professor
	August	DTU's Full UKCRC Clinical Trials Unit Registration has been renewed
		TRG Research Bulletin - Summer 2012
		Study suggests diabetes drug metformin does not protect against cancer
	July	Applications sought for prestigious NIHR Oxford BRC Clinical Fellowship in Diabetes
		Successful Finishing School for Specialist Registrars held in Oxford
		DTU appoints new Senior Clinical Researcher
	June	TECOS celebrates enrolment milestone at the ADA
		DTU staff attend ADA conference in the States
		Prof Holman speaks about ACE trial at ADA conference
	May	Members of DTU accompany University's Vice-Chancellor on China visit
		Local press helps DTU seek volunteers for aspirin trial
		Prof Holman gives opening speech at Chinese Diabetes meeting
		DTU Director joins prestigious Academy of Medical Sciences
		DTU Director speaks at largest ever European Endocrinology conference
	April	Professor Holman gives talk at ESH meeting in London
		DTU Clinician wins Oxford College scholarship
	March	More evidence that gene variations influence metformin response
		DTU Director invited to speak at Abu Dhabi conference
		Successful 2012 Oxford Biomedical Research Centre Open Day
		Senior Clinical Researcher Vacancy
	February	DTU appoints a new Deputy Director
		Professor Holman speaks at tenth annual NNDU meeting in China
	January	Women develop diabetes at higher BMIs than men
		Why Medicine Needs Better Trials and Reporting
2011	December	We are seeking high-calibre applications for the newly-created DTU Deputy Director post
		How FDA Guidance for Developing Diabetes Drugs is Affecting Trial Design
		IDF World Diabetes Congress 2011
	November	American Heart Association Scientific Sessions 2011
		Paediatric Endocrinology and Diabetes 2011
	October	Canadian National Atherosclerosis Forum 2011
	September	Young Diabetologists Forum 2011
		Professor Holman gives invited lecture at the 2011 EASD meeting
		DTU benefits from share of £95m in research funding
	August	ACE Regional Investigator Meetings July 2011
		New offices opened in Beijing
	July	Insulin treatment satisfaction in the 4-T trial
		EXSCEL launches outside the US
	June	Prof. Holman's international contributions recognised by prestigious American Diabetes Association award
		DREAM trial washout results
	May	A qualitative study of how treatment recommendations are followed in clinical trials
	April	Rosiglitazone out-performs Metformin and Glyburide in terms of renal function as an early-stage type 2 diabetes treatment
		TECOS initiation meeting in Prague for new members
	March	Diabetes patients worry about injecting insulin in public more than they do about injecting more frequently
		More effective glycaemic control seen with rosiglitazone is explained by effects on both β-cell function and insulin sensitivity
		Prof. Rury Holman appointed as an NIHR Senior Investigator
	February	Young Diabetologists Forum Finishing School 'well received'
		Professor Holman gives invited talk at the Royal College of Physicians
		Impact of personalised cardiovascular risk estimates on physical activity
		Professor Rury Holman co-chairs the Young Diabetologists Forum Finishing School
	January	Outcomes Model 1.3 released
		Variations in the gene ATM affect the performance of metformin
2010	August	TECOS Update
	July	ACE is seeking ancillary study proposals...
	March	NAVIGATOR trial results published
		NAVIGATOR valsartan results presented at ACC.10 in Atlanta
		NAVIGATOR nateglinide results presented at ACC.10 in Atlanta
		NAVIGATOR results slide set
		NAVIGATOR Baseline paper published
	February	Personal Chair awarded to Dr Andrew Farmer
2009	October	4-T final results published
		Final results of the 4-T trial
		First National ACE Investigator Meeting
		TECOS is seeking ancillary study proposals...
		Rosiglitazone Decreases C-Reactive Protein
	August	Intensive glucose control and macrovascular outcomes in type 2 diabetes
		4-T database lock
		Optimal insulin regimens in type 2 diabetes mellitus
	July	TECOS launched in Europe
	June	HTA report on self-monitoring of blood glucose
		Outcomes Model 1.2.1 released
		HbA1c for the diagnosis of diabetes?
	May	2009 Diabetes State of the Art Course presented by OCDEM and YDF
	April	Risk Engine 2.01 released
	March	New cardiovascular outcome trial with once-weekly exenatide
	February	First ACE patient enrolled 17th February 2009
		Impact of using a non-diabetes-specific risk calculator on eligibility for statin therapy in type 2 diabetes
	January	Commentary on POPADAD study
		Potential impact of omega-3 treatment on cardiovascular disease in type 2 diabetes
		AFORRD primary results published
		Updated version of ADA/EASD consensus algorithm for management of hyperglycaemia
		Prevalence of Glucokinase (GCK) Mutations in Individuals Screened for Fasting Hyperglycaemia
2008	December	TECOS study launched
	November	Prevalence of GCK mutations in fasting hyperglycaemia
		AFORRD results published online
	October	UKCRC Registered Clinical Trials Units website launched
		Ethics approval received for the Acarbose Cardiovascular Evaluation (ACE) trial
		NAVIGATOR Design Paper published
	September	UKPDS shows glucose control and metformin legacy effects
		30-year UKPDS results
	August	Selecting components for composite endpoints
		Diabetic Medicine supplement with eleven UKPDS review articles
	June	DTU to run sitagliptin outcome trial with DCRI
	April	Acarbose Cardiovascular Evaluation (ACE) trial launched
	March	Banting Memorial Lecture Awarded to Rury Holman
	February	OCDEM and YDF present ... Diabetes State of the Art Course
	January	ClinicaL Decisions. Management of Type 2 Diabetes
2007	December	DTU Laboratory awarded Clinical Pathology Assocation (CPA) accreditation
		HOMA Calculator 2.2.2 released
	November	Diabetes Trials Unit awarded full UKCRC CTU Registration
		Consensus algorithm update for thiazolidinediones
		Recommendations for designing tables that report randomized trials
		Outstanding Foreign Investigator Award
	October	Metabolic syndrome and Type 2 diabetes - UKPDS Paper 78
		4-T One Year results published in NEJM
		HOMA Calculator 2.2.1 released
	September	Risk Engine confidence interval methodology published
	August	Stability of Soluble Adhesion Molecules, Selectins, and C-Reactive Protein at Various Temperatures
		Omega-3 PUFA effects on emerging lipid cardiovascular risk markers in type 2 diabetes
	July	GAD autoantibodies and epitope reactivities in T2DM (UKPDS 77)
		Self blood glucose monitoring in type 2 diabetes - the DiGEM study
	June	UKPDS Outcomes Model version 1.2 available
		Sad news - Carole Cull died on the 9th June 2007
	May	Framingham, SCORE and DECODE CVD risk estimates in type 2 diabetes
	January	Omega-3 PUFA effects on haematological and thrombogenic factors in type 2 diabetes
		Association Analysis of the HLA Gene Region in LADA
2006	December	AFORRD results presented at IDF WDC2006 Cape Town
		DREAM drug washout study results
	November	PON2 polymorphisms and renal dysfunction (UKPDS 76)
		Characteristics of Type 2 diabetic patients in North America and Europe (ADOPT)
	October	Is there a need for a clinical screening tool for autoimmune diabetes in adults?
		Hypoglycaemia in type 2 diabetes (UKPDS 73)
	September	Download DREAM trial results slides
		DREAM trial results
	August	Obesity and CRP in type 2 diabetes (ADOPT)
	July	Impact of glycemic control on macrovascular disease
	June	ADA/EASD consensus algorithm for managing hyperglycaemia
		Impact of Visual Acuity on Quality of Life
		Combined effects of glycaemia and blood pressure in type 2 diabetes (UKPDS 75)
	May	VNTR and LADA susceptibility
		Risk factors for renal dysfunction (UKPDS 74)
		Joint Servier/OCDEM Meeting for Specialist Registrars
		Thames Valley Diabetes Research Network
		Long-term efficacy of sulfonylureas
	January	Comment on PROactive study results
2005	October	UKPDS Outcomes Model manual available online
	September	UKPDS Outcomes Model 1.1 released
	July	Reporting of diabetes on death certificates
	June	Non-HDL Cholesterol Is Less Informative
	May	UKPDS paper 72 published in Diabetologia
		Glycaemic control after addition of sulphonylurea to metformin
	April	UKPDS paper 70 published in Diabetologia
		UKPDS paper 71 published in Diabetologia
	February	UKPDS paper 67 published in Diabetic Medicine
	January	Framingham risk equations can underestimate CHD risk in diabetes
2004	December	UKPDS Outcomes Model software 1.0 released
		Paper on aspirin use in Type 2 diabetes published in Diabetic Medicine
		GADA prevalence in type 2 diabetes (ADOPT)
	November	UKPDS paper 69 published in Archives of Ophthalmology
		AFORRD Study commences recruitment
		4-T Study commences recruitment
	October	UKPDS paper 68 published in Diabetologia
	September	DREAM protocol paper published in Diabetologia
	June	HOMA Calculator 2.2 released
		HOMA Calculator released
	February	UKPDS Risk Engine 2.0 released
	January	OTTT paper published in Diabetes Care
		The AFORRD study
		UKPDS paper 66 published in Diabetes Care
2003	September	New UKPDS results reported at the IDF
	August	Risk Engine 1.2 released
	July	Full programme for third Mount Hood meeting announced
	June	The Mount Hood III modelling meeting will be hosted by the DTU in Oxford in August
		UKPDS paper 65 published in Diabetic Medicine
		UKPDS report on pregnancy outcomes
	May	Risk Engine 1.1 released
	March	Autoantibodies to islet cell antigen SOX-13 paper published in Diabetic Medicine
	February	Move to new Institute
	January	UKPDS paper 64 published in Kidney International
2002	October	ISAT Trial results published
	September	EuroDREAM project office
	July	UKPDS paper 60 published in Stroke
	June	DTU abstracts at ADA 2002
	May	Appointment of the first Robert Turner Professor of Diabetes
		UKPDS Risk Engine FAQ available
		Homocysteine as a risk factor for cardiovascular disease publication
	March	LDS Close out
		UKPDS Risk Engine v1.0 released
2000	September	FHS results presented in Jerusalem
1997	December	FHS sulphonylurea paper published
		FHS healthy-living paper published
		FHS overview paper published