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UK Prospective Diabetes Study



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Precision medicine study reveals how our genetics can alter action of metformin, the most commonly used Type 2 diabetes drug

09-Aug-2016
News Image RDM researchers have uncovered new genetic evidence of how the benefits of the world's most commonly used Type 2 diabetes drug may vary between individuals.

Metformin, a drug used by hundreds of millions of people with Type 2 diabetes worldwide, has been in use for over 50 years....

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New version of the UKPDS Outcomes Model published

22-Jun-2013
News Image The new UKPDS-OM2 has significant advantages over the existing model, as it captures more outcomes, is based on longer follow-up data, and more comprehensively captures the progression of diabetes. Its use will permit detailed and reliable lifetime simulations of key health outcomes in people with type 2 diabetes mellitus....

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New study suggests one in six people with newly-diagnosed diabetes may have had a silent heart attack in the past

01-Feb-2013
News Image Research published online this week by DTU and Australian researchers has found that one in six people with newly-diagnosed type 2 diabetes may have experienced a silent myocardial infarction (SMI) - a heart attack without chest pain or symptoms - in the past.

Published in the journal Circulation, the study examined data from 1,967 people with type 2 diabetes who enrolled in the landmark 30-year UK Prospective Diabetes Study (UKPDS)....

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UKPDS shows glucose control and metformin legacy effects

10-Sep-2008
News Image The UKPDS 10-year post-trial monitoring results were presented at the 44th EASD meeting in Rome on Wednesday 10th September 2008.

They showed continuing benefit of earlier improved glucose control, with emergent significant risk reductions for myocardial infarction and all-cause mortality, despite loss of within trial blood glucose and antihyperglyaemic therapy differences - a legacy effect....

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Diabetic Medicine supplement with eleven UKPDS review articles

01-Aug-2008
News Image The August 2008 issue of Diabetic Medicine includes a UKPDS Supplement, edited by Rury Holman and Peter Watkins. This Supplement contains eleven specially commissioned articles that review many of the contributions that have been made by UKPDS in different areas of interest....

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Metabolic syndrome and Type 2 diabetes - UKPDS Paper 78

30-Oct-2007
News Image Impact of the Metabolic Syndrome on Macrovascular and Microvascular Outcomes in Type 2 Diabetes Mellitus. UKPDS 78
Carole A....

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PON2 polymorphisms and renal dysfunction (UKPDS 76)

17-Nov-2006
News Image Paraoxonase2 (PON2) Polymorphisms and Development of Renal Dysfunction in Type 2 Diabetes: UKPDS 76
Calle R, McCarthy MI, Banerjee P, Zeggini E, Cull CA, Thorne KI, Wiltshire S, Terra S, Meyer D, Richmond J, Mancuso J, Milos P, Fryburg D, Holman RR
Diabetologia 2006;49:2892-2899

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Is there a need for a clinical screening tool for autoimmune diabetes in adults?

30-Oct-2006


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Hypoglycaemia in type 2 diabetes (UKPDS 73)

26-Oct-2006
News Image Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS 73
Wright AD, Cull CA, Macleod KM, Holman RR for the UKPDS Group
Journal of Diabetes and its Complications 2006;20:402-408

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Combined effects of glycaemia and blood pressure in type 2 diabetes (UKPDS 75)

01-Jun-2006
News Image Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75)
I.M....

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VNTR and LADA susceptibility

31-May-2006
News Image The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults
Minal Desai, Eleftheria Zeggini, Virginia A. Horton, Katharine R....

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Risk factors for renal dysfunction (UKPDS 74)

30-May-2006
News Image Risk Factors for Renal Dysfunction in Type 2 Diabetes : UK Prospective Diabetes Study 74
Ravi Retnakaran, Carole A. Cull, Kerensa I....

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Reporting of diabetes on death certificates

15-Jul-2005
News Image Reporting of diabetes on death certificates using data from the UK Prospective Diabetes Study
M. J....

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UKPDS paper 72 published in Diabetologia

24-May-2005
News Image Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72)
P.M....

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UKPDS paper 70 published in Diabetologia

20-Apr-2005
News Image Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control
T. M....

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UKPDS paper 71 published in Diabetologia

20-Apr-2005
News Image IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes
G. F....

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UKPDS paper 67 published in Diabetic Medicine

22-Feb-2005
News Image Insulin sensitivity at diagnosis of Type 2 diabetes is not associated with subsequent cardiovascular disease (UKPDS 67).
A....

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UKPDS paper 69 published in Archives of Ophthalmology

01-Nov-2004
News Image Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69.

Matthews DR, Stratton IM, Aldington SJ, Holman RR, Kohner EM; UK Prospective Diabetes Study Group....

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UKPDS paper 68 published in Diabetologia

01-Oct-2004
News Image A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS 68)
P. M....

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UKPDS paper 66 published in Diabetes Care

01-Jan-2004
News Image Risk Factors for Myocardial Infarction Case Fatality and Stroke Case Fatality in Type 2 Diabetes.
Richard J....

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New UKPDS results reported at the IDF

23-Sep-2003
News Image

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UKPDS paper 65 published in Diabetic Medicine

04-Jun-2003
News Image The impact of diabetes-related complications on healthcare costs: results from the United Kingdom Prospective Diabetes Study (UKPDS Study No. 65)
P....

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UKPDS report on pregnancy outcomes

04-Jun-2003
News Image Poor pregnancy outcome for women with Type 2 diabetes.
D....

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UKPDS paper 64 published in Kidney International

15-Jan-2003
News Image UKPDS 64 Development and Progression of Nephropathy in Type 2 Diabetes: Observation and Modelling from the United Kingdom Prospective Diabetes Study
Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR
Kidney International (2003); 63: 225-232

BACKGROUND: The progression of nephropathy from diagnosis of type 2 diabetes has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death....

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UKPDS paper 60 published in Stroke

09-Jul-2002
News Image UKPDS 60 Risk of stroke in type 2 diabetes estimated by the UKPDS risk engine
Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HAW, Holman RR
Stroke (2002); 33: 1776-1781

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