DTU
DTU

Trial Evaluating Cardiovascular Outcomes With Sitagliptin

Joint chairs:Rury Holman
Eric Peterson (Previously Robert Califf)

Sponsor:Merck Sharp & Dohme, a subsidiary of Merck

Funder:Merck Sharp & Dohme

Reference numbers:NCT00790205
EudraCT 2008-006719-20

TECOS evaluated the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease.

Design

Randomised, placebo-controlled global clinical trial performed in 14,735 patients who were enrolled between 2009 and 2012. TECOS was coordinated jointly by the DTU and the Duke Clinical Research Institute (DCRI) and conducted in 38 countries.

Results

The results of TECOS were reported at the 2015 meeting of the ADA. It met its primary safety endpoint of non-inferiority for the primary composite cardiovascular endpoint of (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalisation for unstable angina). Rates of hospitalization for heart failure, acute pancreatitis and pancreatic cancer did not differ between the two groups. The primary results paper is available here.

Manuscript proposals

The TECOS Publications Committee are happy to review proposals for potential new manuscripts. Proposals should be submitted on a TECOS Trial Topic Request Form emailed to peter.hoffmann@duke.edu

News

TECOS primary results slide set

08-Jun-2015
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A slide set displaying the primary results of TECOS, as presented at the ADA on Mon 8th June 2015, is freely-available for download via the link below.

[Link]

TECOS primary results presented at the ADA

08-Jun-2015
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The TECOS study group presented the primary results today to an audience of over 6,500 attendees at the 75th Annual Scientific Sessions of the American Diabetes Society in Boston, Massachusetts, US.

ABSTRACT

BACKGROUND....

[Read more...]

TECOS Primary Results to be presented at the ADA

04-Feb-2015
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The TECOS primary results will be presented at the 2015 ADA 75th Scientific Sessions in Boston, US, on the afternoon of Monday 8th June at 4:30 pm.


[News archive]