In Diabetes, Obesity and Metabolism, we investigate how insulin treatment satisfaction varies between biphasic, prandial or basal insulin treatment groups in the Treat-To-Target in Type 2 diabetes (4-T) trial.
In total, 708 patients taking metformin and sulfonylurea were randomized to biphasic, prandial, or basal insulin. At one year, Insulin Treatment Satisfaction Questionnaires (ITSQs) were completed by the patients, where lower scores indicated lower treatment satisfaction. We tested the results for differences between the three groups, adjusting for age, gender, ethnicity and education.
The results show that patients taking prandial insulin on average reported lower scores compared with the basal or biphasic groups. Median questionnaire scores were also lower in patients with a gain in BMI over the year, and in those with episodes of hypoglycaemia.
These findings demonstrate the impact of treatment on lifestyle, which must be considered as a factor in the choice of an insulin regimen.