DTU
DTU

Can the undesirable effects of steroid therapy be mitigated?

13-Mar-2023

Glucocorticoid induced hyperglycaemia and the development of type 2 diabetes mellitus are major downsides to the use of steroids for the treatment of acute and chronic inflammatory diseases. In a randomised controlled trial Professor Tomlinson and colleagues working with Professor Holman and the Diabetes Trials Unit have investigated whether AZD4017, an 11ß-HSD1 inhibitor, can attenuate glucocorticoid-associated side effects on blood pressure, glycaemia, bone, and lipid metabolism, assessed after 7 days therapy in healthy men. The results, published in Nature Communications, show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects.


[Read the manuscript here]