DTU
DTU

A Diabetes Outcomes Progression Trial

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2011

Rosiglitazone out-performs Metformin and Glyburide in terms of renal function as an early-stage type 2 diabetes treatment

19-Apr-2011
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ADOPT (A Diabetes Outcomes Prevention Trial) showed that initial treatment with just rosiglitazone provided more durable glycemic control than metformin or glyburide in patients with recently diagnosed type 2 diabetes. In CJASN, we examine the differences in albumin excretion, renal function and blood pressure over the course of 5 years between the treatment groups....

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More effective glycaemic control seen with rosiglitazone is explained by effects on both β-cell function and insulin sensitivity

22-Mar-2011
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The ADOPT study (A Diabetes Outcomes Prevention Trial) showed that treatment with rosiglitazone alone provided somewhat more effective glycaemic control than metformin or glyburide alone, in patients with recently diagnosed type 2 diabetes. In a paper published recently in Diabetes, we examined changes in β-cell function and insulin sensitivity among the three treatments in ADOPT....

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2009

Rosiglitazone Decreases C-Reactive Protein

09-Oct-2009
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Rosiglitazone Decreases C-Reactive Protein to a Greater Extent Relative to Glyburide and Metformin over Four-Years in Spite of Greater Weight Gain: Observations from ADOPT (A Diabetes Outcome Progression Trial).
Steven E....

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2006

Selected slides from the ADOPT plenary session

05-Dec-2006

Selected slides from the ADOPT plenary session at the IDF World Diabetes Congress 2006 available

[Link]

ADOPT results announced

04-Dec-2006

The ADOPT results were announced at the IDF 19th World Diabetes Congress and simultaneously published in the New England Journal of Medicine.

[Link]

Characteristics of Type 2 diabetic patients in North America and Europe

01-Dec-2006

[Link]

Obesity and the association of CRP and the metabolic syndrome in T2DM

01-Aug-2006

[Link]

Patient follow up completed

01-Jul-2006

2004

GADA prevalence in type 2 diabetes (ADOPT)

01-Dec-2004
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Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
Zinman B, Kahn SE, Haffner SM, O'Neill MC, Heise MA, Freed MI; ADOPT Study Group
Diabetes 2004;53:3193-3200

[Link]

Phenotypic characteristics of GAD-positive T2DM patients

01-Dec-2004

[Link]

2002

ADOPT protocol published in Diabetes Care

01-Oct-2002

A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes.
Viberti,G; Kahn,SE; Greene,DA; Herman,WH; Zinman,B; Holman,RR; Haffner,SM; Levy,D; Lachin,JM; Berry,RA; Heise,MA; Jones,NP; Freed,MI
Diabetes Care....

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