DTU
DTU

EXenatide Study of Cardiovascular Event Lowering

Manuscripts (17 of 17)

Years :

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2020

Exploring the Possible Impact of Unbalanced Open-Label Drop-In of Glucose-Lowering Medications on EXSCEL Outcomes
M. Angelyn Bethel, Susanna R. Stevens, John B. Buse, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Yuliya Lokhnygina, Robert J. Mentz, Rishi A. Patel, Peter Öhman, Guntram Schernthaner, Albert LeCube, Adrian F. Hernandez, Rury R. Holman
Circulation 2020;141:1360-1370. Published:28-Apr-2020. Epub:26-Feb-2020. PMID:32098501. doi:10.1161/CIRCULATIONAHA.119.043353

Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights from EXSCEL
Eberhard Standl, Susanna R. Stevens, Yuliya Lokhnygina, Angelyn Bethel, John B. Buse, Stephanie M. Gustavson, Aldo P. Maggioni, Robert J. Mentz, Adrian F. Hernandez, Rury R. Holman, for the EXSCEL Study Group
Diabetes Care 2020;43:643-652. Published:Mar-2020. Epub:27-Dec-2019. PMID:31882409. doi:10.2337/dc19-1079

Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)
Shelby D. Reed, Yanhong Li, Helen A. Dakin, Frauke Becker, Jose Leal, Stephanie M. Gustavson, Bernt Kartman, Eric Wittbrodt, Robert J. Mentz, Neha J. Pagidipati, M. Angelyn Bethel, Alastair M. Gray, Rury R. Holman, Adrian F. Hernandez, for the EXSCEL Study Group
Diabetes Care 2020;43:374-381. Published:Feb-2020. Epub:05-Dec-2019. PMID:31806653. doi:10.2337/dc19-0950

Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial
M. Angelyn Bethel, Robert J. Mentz, Peter Merrill, John B. Buse, Juliana C. Chan, Shaun G. Goodman, Nayyar Iqbal, Neli Jakuboniene, Brian Katona, Yuliya Lokhnygina, Renato D. Lopes, Aldo P. Maggioni, Peter Ohman, Tsvetalina Tankova, George L. Bakris, Adrian F. Hernandez, and Rury R. Holman
Diabetes Care 2020;43:446-452. Published:Feb-2020. Epub:22-Nov-2019. PMID:31757838. doi:10.2337/dc19-1065

Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL
Idzerda NMA, Clegg LE, Hernandez AF, Bakris G, Penland RC, Boulton DW, Bethel MA, Holman RR, Heerspink HJL
Diabetes Obes Metab. 2020;22:798-806. Epub:07-Jan-2020. PMID:31912603. doi:10.1111/dom.13958

2019

Clinical Outcomes in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: Results From the EXSCEL Trial
Badjatiya A, Merrill P, Buse JB, Goodman SG, Katona B, Iqbal N, Pagidipati NJ, Sattar N, Holman RR, Hernandez AF, Mentz RJ, Patel MR, Jones WS
Circ Cardiovasc Interv. 2019;12:e008018. Published:Dec-2019. Epub:22-Nov-2019. PMID:31752517. doi:10.1161/CIRCINTERVENTIONS.119.008018

Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial
Fudim M, White J, Pagidipati NJ, Lokhnygina Y, Wainstein J, Murin J, Iqbal N, Öhman P, Lopes RD, Reicher B, Holman RR, Hernandez AF, Mentz RJ
Circulation 2019;140:1613-1622. Published:12-Nov-2019. Epub:23-Sep-2019. PMID:31542942. doi:10.1161/CIRCULATIONAHA.119.041659

Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial
Clegg LE, Penland RC, Bachina S, Boulton DW, Thuresson M, Heerspink HJL, Gustavson S, Sjöström CD, Ruggles JA, Hernandez AF, Buse JB, Mentz RJ, Holman RR.
Cardiovasc Diabetol 2019;18:138. Published:22-Oct-2019. PMID:31640705. doi:10.1186/s12933-019-0942-x

Changes in Serum Calcitonin Concentrations, Incidence of Medullary Thyroid Carcinoma, and Impact of Routine Calcitonin Concentration Monitoring in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL)
M. Angelyn Bethel, Rishi A Patel, Brian G. Katona, Vivian P. Thompson, Stephanie M. Gustavson, Peter Ohman, Nayyar Iqbal John B. Buse, Rury R. Holman; for the EXSCEL Study Group
Diabetes Care 2019;42 :1075-1080. Published:Jun-2019. Epub:22-Apr-2019. PMID:31010875. doi:10.2337/dc18-2028

Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
Lindsay E. Clegg, Hiddo J.L. Heerspink, Robert C. Penland, Weifeng Tang, David W. Boulton, Srinivas Bachina, Robert D. Fox, Peter Fenici Marcus Thuresson, Robert J. Mentz, Adrian F. Hernandez, and Rury R. Holman
Diabetes Care 2019;42:318-326. Published:Feb-2019. Epub:06-Dec-2018. PMID:30523029. doi:10.2337/dc18-1871

2018

Effects of Once-Weekly Exenatide on Clinical Outcomes in Patients with Preexisting Cardiovascular Disease: A Prespecified Analysis From EXSCEL
Robert J Mentz, Vivian P. Thompson, David Aguilar, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Alice P. S. Kong, Peter Öhman, Naveed Sattar, Russell S Scott, Yee Weng Wong, Rury R. Holman, and Adrian F. Hernandez
Circulation 2018;138:2576-2578. Published:27-Nov-2018. Epub:28-Aug-2018. PMID:30571356. doi:10.1161/CIRCULATIONAHA.118.036811

Effect of Once-Weekly Exenatide on Clinical Outcomes According to Baseline Risk in Patients With Type 2 Diabetes Mellitus: Insights From the EXSCEL Trial
Robert J. Mentz, M. Angelyn Bethel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, João S. Felício, Shaun G. Goodman, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Renato D. Lopes, Aldo P. Maggioni, Peter Öhman, Neha J. Pagidipati, Neil R. Poulter, Ambady Ramachandran, Barry Reicher, Rury R. Holman, Adrian F. Hernandez, on behalf of the EXSCEL Study Group
J Am Heart Assoc 2018;7:e009304.. Published:02-Oct-2018. Epub:20-Sep-2018. PMID:30371301. doi:10.1161/JAHA.118.009304

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis
M. Angelyn Bethel, Rishi A. Patel, Peter Merrill, Yuliya Lokhnygina, John B. Buse, Robert J. Mentz, Neha J. Pagidipati, Juliana C. Chan, Stephanie M. Gustavson, Nayyar Iqbal, Aldo P. Maggioni, Peter Öhman, Neil R. Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F. Hernandez, and Rury R. Holman, for the EXSCEL Study Group
Lancet Diabetes Endocrinol. 2018;6:105-113. Published:Feb-2018. Epub:06-Dec-2017. PMID:29221659. doi:10.1016/S2213-8587(17)30412-6
[Slides]

2017

Once-Weekly Exenatide and Cardiovascular Outcomes in Type 2 Diabetes – Authors' reply
Rury R. Holman, M. Angelyn Bethel, Adrian F. Hernandez,
N Eng J Med 2017;377:2502. Published:21-Dec-2017. PMID:29262286. doi:10.1056/NEJMc1714163

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes
Rury R. Holman, M. Angelyn Bethel, Robert J. Mentz, Vivian P. Thompson, Yuliya Lokhnygina, John B. Buse, Juliana C. Chan, Jasmine Choi, Stephanie M. Gustavson, Nayyar Iqbal, Aldo P. Maggioni, Steven P. Marso, Peter Öhman, Neha J. Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, and Adrian F. Hernandez, for the EXSCEL Study Group
N Engl J Med 2017;377:1228-39. Published:28-Sep-2017. Epub:14-Sep-2017. PMID:28910237. doi:10.1056/NEJMoa1612917
[Slides]

Baseline characteristics of patients enrolled in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)
Robert J. Mentz , M. Angelyn Bethel, Stephanie Gustavson, Vivian P. Thompson, Neha J. Pagidipati, John B. Buse, Juliana C. Chan, Nayyar Iqbal, Aldo P. Maggioni, Steve P. Marso, Peter Ohman, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F. Hernandez, Rury R. Holman
Am Heart J. 2017;187:1-9. Published:14-Sep-2017. Epub:12-Feb-2017. PMID:28454792. doi:10.1016/j.ahj.2017.02.005

2016

Rationale and Design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) Trial
Rury R. Holman, M. Angelyn Bethel, Jyothis George, Harald Sourij, Zoë Doran, Joanne Keenan, Nardev S. Khurmi, Robert J. Mentz, Abderrahim Oulhaj, John B. Buse, Juliana C. Chan, Nayyar Iqbal, Sudeep Kundu, Aldo P. Maggioni, Steven P. Marso, Peter Öhman, Michael J. Pencina, Neil Poulter, Lisa E. Porter, Ambady Ramachandran, Bernard Zinman, Adrian F.Hernande
American Heart Journal 2016;174:103-110. Published:Apr-2016. Epub:21-Dec-2015. PMID:26995376. doi:10.1016/j.ahj.2015.12.009